Arianna Lockhart
Overview
Explore the profile of Arianna Lockhart including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
347
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0
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Recent Articles
1.
Schindler N, Tonn M, Kellner V, Fung J, Lockhart A, Vydzhak O, et al.
Nat Commun
. 2023 Mar;
14(1):1227.
PMID: 36869098
Single ribonucleoside monophosphates (rNMPs) are transiently present in eukaryotic genomes. The RNase H2-dependent ribonucleotide excision repair (RER) pathway ensures error-free rNMP removal. In some pathological conditions, rNMP removal is impaired....
2.
Lockhart A, Pires V, Bento F, Kellner V, Luke-Glaser S, Yakoub G, et al.
Cell Rep
. 2019 Nov;
29(9):2890-2900.e5.
PMID: 31775053
RNA-DNA hybrids are tightly regulated to ensure genome integrity. The RNase H enzymes RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA hybrids. Loss of RNase...
3.
Lafuente-Barquero J, Luke-Glaser S, Graf M, Silva S, Gomez-Gonzalez B, Lockhart A, et al.
PLoS Genet
. 2017 Dec;
13(12):e1007136.
PMID: 29281624
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA...
4.
Graf M, Bonetti D, Lockhart A, Serhal K, Kellner V, Maicher A, et al.
Cell
. 2017 Jul;
170(1):72-85.e14.
PMID: 28666126
Maintenance of a minimal telomere length is essential to prevent cellular senescence. When critically short telomeres arise in the absence of telomerase, they can be repaired by homology-directed repair (HDR)...
5.
Maicher A, Lockhart A, Luke B
Biochim Biophys Acta
. 2014 Apr;
1839(5):387-94.
PMID: 24698720
Despite the fact that telomeres carry chromatin marks typically associated with silent heterochromatin, they are actively transcribed into TElomeric Repeat containing RNA (TERRA). TERRA transcription is conserved from yeast to...
6.
Gobbini E, Cesena D, Galbiati A, Lockhart A, Longhese M
DNA Repair (Amst)
. 2013 Aug;
12(10):791-9.
PMID: 23953933
DNA double-strand breaks (DSBs) are highly hazardous for genome integrity because they have the potential to cause mutations, chromosomal rearrangements and genomic instability. The cellular response to DSBs is orchestrated...