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Apostolos Komnos

Explore the profile of Apostolos Komnos including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 28
Citations 521
Followers 0
Related Specialties
Critical Care
Neurology
General Medicine
Top 10 Co-Authors
Panagiotis Papamichalis
Efthimios Dardiotis
Dimitrios Papadopoulos
Konstantinos Paterakis
George Dimopoulos
Mihai G Netea
Apostolia-Lemonia Skoura
Georgios Tsivgoulis
Evangelos J Giamarellos-Bourboulis
Tilemachos Zafeiridis
Published In
Crit Care Med
Crit Care
World J Clin Cases
Pharmacogenet Genomics
Cell Rep Med
Affiliations
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Recent Articles
1.
Sepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response
Brandes-Leibovitz R, Riza A, Yankovitz G, Pirvu A, Dorobantu S, Dragos A, et al.
Cell Rep Med . 2024 Nov; 5(11):101829. PMID: 39566468
Patients with sepsis differ in their clinical presentations and immune dysregulation in response to infection, but the fundamental processes that determine this heterogeneity remain elusive. Here, we aim to understand...
2.
Modulation of Metabolomic Profile in Sepsis According to the State of Immune Activation
Kranidioti E, Ricano-Ponce I, Antonakos N, Kyriazopoulou E, Kotsaki A, Tsangaris I, et al.
Crit Care Med . 2024 Oct; 52(11):e536-e544. PMID: 39418210
Objective: To investigate the metabolomic profiles associated with different immune activation states in sepsis patients. Design: Subgroup analysis of the PROVIDE (a Personalized Randomized trial of Validation and restoration of...
3.
Quality metrics in the management of acute stroke in Greece during the first 5 years of Registry of Stroke Care Quality (RES-Q) implementation
Palaiodimou L, Kargiotis O, Katsanos A, Kiamili A, Bakola E, Komnos A, et al.
Eur Stroke J . 2023 Feb; 8(1 Suppl):5-15. PMID: 36793743
Introduction: Establishment of a prospective stroke registry may promote the documentation and improvement of acute stroke care. We present the status of stroke management in Greece using the Registry of...
4.
Prevention, diagnostic evaluation, management and prognostic implications of liver disease in critically ill patients with COVID-19
Valsamaki A, Xanthoudaki M, Oikonomou K, Vlachostergios P, Papadogoulas A, Katsiafylloudis P, et al.
World J Clin Cases . 2023 Feb; 11(3):514-527. PMID: 36793637
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, broke out in December 2019 in Wuhan city of China and spread rapidly worldwide. Therefore, by March 2020,...
5.
Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial
Leventogiannis K, Kyriazopoulou E, Antonakos N, Kotsaki A, Tsangaris I, Markopoulou D, et al.
Cell Rep Med . 2022 Nov; 3(11):100817. PMID: 36384100
The state of immune activation may guide targeted immunotherapy in sepsis. In a double-blind, double-dummy randomized clinical study, 240 patients with sepsis due to lung infection, bacteremia, or acute cholangitis...
6.
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial
Chastre J, Francois B, Bourgeois M, Komnos A, Ferrer R, Rahav G, et al.
Crit Care . 2022 Nov; 26(1):355. PMID: 36380312
Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia...
7.
Impact of secondary sepsis on mortality in adult intensive care unit patients
Karvouniaris M, Papadopoulos D, Koulenti D, Chatzimichail M, Papamichalis P, Ntafoulis N, et al.
Intensive Crit Care Nurs . 2022 Nov; 75:103345. PMID: 36357233
Rationale: Septic patients admitted to the intensive care unit (ICU) suffer from immune dysregulation, potentially leading to a secondary sepsis episode. This study aims to (i) assess the secondary sepsis...
8.
ICU-Associated Gram-Negative Bloodstream Infection: Risk Factors Affecting the Outcome Following the Emergence of Colistin-Resistant Isolates in a Regional Greek Hospital
Karvouniaris M, Poulakou G, Tsiakos K, Chatzimichail M, Papamichalis P, Katsiaflaka A, et al.
Antibiotics (Basel) . 2022 Mar; 11(3). PMID: 35326868
Intensive care unit patients may present infections by difficult-to-treat-resistant Gram-negative microorganisms. Colistin resurfaced as a last resort antibiotic for the treatment of multi-drug-resistant Gram-negative bacteria. However, colistin might not improve...
9.
ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically lll COVID-19 Patients
Karakike E, Dalekos G, Koutsodimitropoulos I, Saridaki M, Pourzitaki C, Papathanakos G, et al.
J Innate Immun . 2021 Dec; 14(3):218-228. PMID: 34852352
Background: Macrophage activation-like syndrome (MALS) and complex immune dysregulation (CID) often underlie acute respiratory distress (ARDS) in COVID-19. We aimed to investigate the effect of personalized immunotherapy on clinical improvement...
10.
Rapid Test Ag 2019-nCoV (PROGNOSIS, BIOTECH, Larissa, Greece); Performance Evaluation in Hospital Setting with Real Time RT-PCR
Kyritsi M, Vontas A, Voulgaridi I, Matziri A, Komnos A, Babalis D, et al.
Int J Environ Res Public Health . 2021 Sep; 18(17). PMID: 34501741
Introduction: Rapid antigen tests (RATs) are convenient for SARS-CoV-2 detection because they are simpler and faster than nucleic acid amplification tests (NAATs). This study aimed to assess the accuracy of...