Antonio Rego
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Explore the profile of Antonio Rego including associated specialties, affiliations and a list of published articles.
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12
Citations
121
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Recent Articles
1.
Amaral L, Mendes F, Corte-Real M, Rego A, Outeiro T, Chaves S
Chemosphere
. 2024 Aug;
364:143039.
PMID: 39117080
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies, which predominantly consist of aggregated forms of the protein alpha-synuclein...
2.
Chaves S, Rego A, Santos-Pereira C, Sousa M, Corte-Real M
Cell Death Differ
. 2024 May;
32(2):207-218.
PMID: 38714881
The study of cell death mechanisms in fungi, particularly yeasts, has gained substantial interest in recent decades driven by the potential for biotechnological advancements and therapeutic interventions. Examples include the...
3.
Rego A, Ribeiro A, Corte-Real M, Chaves S
Apoptosis
. 2022 Jul;
27(9-10):778-786.
PMID: 35796799
Acetic acid and hydrogen peroxide are the most common stimuli to induce apoptosis in yeast. The initial phase of this cell death process is characterized by the maintenance of plasma...
4.
Chaves S, Rego A, Martins V, Santos-Pereira C, Sousa M, Corte-Real M
Front Cell Dev Biol
. 2021 Jul;
9:642375.
PMID: 34249904
Acetic acid has long been considered a molecule of great interest in the yeast research field. It is mostly recognized as a by-product of alcoholic fermentation or as a product...
5.
Rego A, Mendes F, Costa V, Chaves S, Corte-Real M
Oxid Med Cell Longev
. 2020 Apr;
2020:7095078.
PMID: 32318242
The yeast undergoes a mitochondrial-dependent regulated cell death (RCD) exhibiting typical markers of mammalian apoptosis. We have previously shown that ceramide production contributes to RCD induced by acetic acid and...
6.
Costa A, Machado N, Rego A, Sousa M, Corte-Real M, Chaves S
DNA Repair (Amst)
. 2018 Dec;
73:28-33.
PMID: 30502926
Cisplatin is a highly effective chemotherapeutic drug acting as a DNA-damaging agent that induces apoptosis of rapidly proliferating cells. Unfortunately, cellular resistance still occurs. Mutations in p53 in a large...
7.
Rego A, Cooper K, Snider J, Hannun Y, Costa V, Corte-Real M, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2018 Mar;
1863(6):576-583.
PMID: 29496584
Changes in sphingolipid metabolism have been linked to modulation of cell fate in both yeast and mammalian cells. We previously assessed the role of sphingolipids in cell death regulation using...
8.
Rego A, Duarte A, Azevedo F, Sousa M, Corte-Real M, Chaves S
Microb Cell
. 2017 Mar;
1(9):303-314.
PMID: 28357256
Acetic acid triggers apoptotic cell death in , similar to mammalian apoptosis. To uncover novel regulators of this process, we analyzed whether impairing MAPK signaling affected acetic acid-induced apoptosis and...
9.
Rego A, Trindade D, Chaves S, Manon S, Costa V, Sousa M, et al.
FEMS Yeast Res
. 2013 Oct;
14(1):160-78.
PMID: 24103214
It has been established that sphingolipids are engaged in the regulation of apoptosis both as direct executors and as signalling molecules. However, the peculiarities of this class of bioactive lipids,...
10.
Pacheco A, Azevedo F, Rego A, Santos J, Chaves S, Corte-Real M, et al.
PLoS One
. 2013 Sep;
8(9):e74240.
PMID: 24040213
Specific ceramides are key regulators of cell fate, and extensive studies aimed to develop therapies based on ceramide-induced cell death. However, the mechanisms regulating ceramide cytotoxicity are not yet fully...