Anthony Scime
Overview
Explore the profile of Anthony Scime including associated specialties, affiliations and a list of published articles.
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26
Citations
2063
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0
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Recent Articles
1.
Bhattacharya D, Shah V, Oresajo O, Scime A
Nat Commun
. 2021 Oct;
12(1):5977.
PMID: 34645816
Muscle diseases and aging are associated with impaired myogenic stem cell self-renewal and fewer proliferating progenitors (MPs). Importantly, distinct metabolic states induced by glycolysis or oxidative phosphorylation have been connected...
2.
Bhattacharya D, Scime A
Front Cell Dev Biol
. 2020 Jul;
8:480.
PMID: 32612995
Mitochondria are crucial organelles that control cellular metabolism through an integrated mechanism of energy generation via oxidative phosphorylation. Apart from this canonical role, it is also integral for ROS production,...
3.
Cantini G, Di Franco A, Mannelli M, Scime A, Maggi M, Luconi M
Front Cell Dev Biol
. 2020 Jun;
8:332.
PMID: 32478073
Adipose tissue in physiological and in metabolically altered conditions (obesity, diabetes, metabolic syndrome) strictly interacts with the developing tumors both systemically and locally. In addition to the cancer-associated fibroblasts, adipose...
4.
Bhattacharya D, Scime A
Front Endocrinol (Lausanne)
. 2019 Dec;
10:773.
PMID: 31849832
The last few decades have witnessed an outstanding advancement in our understanding of the hallmarks of endocrine cancers. This includes the epithelial to mesenchymal transition (EMT), a process that alters...
5.
Bhattacharya D, Ydfors M, Hughes M, Norrbom J, Perry C, Scime A
Physiol Rep
. 2017 Mar;
5(5).
PMID: 28270591
Increased mitochondrial content is a hallmark of exercise-induced skeletal muscle remodeling. For this process, considerable evidence underscores the involvement of transcriptional coactivators in mediating mitochondrial biogenesis. However, our knowledge regarding...
6.
Porras D, Abbaszadeh M, Bhattacharya D, DSouza N, Edjiu N, Perry C, et al.
Stem Cells
. 2017 Feb;
35(5):1378-1391.
PMID: 28233396
We show that the transcriptional corepressor p107 orchestrates a metabolic checkpoint that determines adipocyte lineage fates for non-committed progenitors. p107 accomplishes this when stem cell commitment would normally occur in...
7.
Downey J, Lauzier D, Kloen P, Klarskov K, Richter M, Hamdy R, et al.
Bone
. 2014 Dec;
71:164-70.
PMID: 25445454
Skeletal muscle has strong regenerative capabilities. However, failed regeneration can lead to complications where aberrant tissue forms as is the case with heterotopic ossification (HO), in which chondrocytes, osteoblasts and...
8.
De Sousa M, Porras D, Perry C, Seale P, Scime A
Stem Cells
. 2014 Jan;
32(5):1323-36.
PMID: 24449206
Thermogenic (beige and brown) adipocytes protect animals against obesity and metabolic disease. However, little is known about the mechanisms that commit stem cells toward different adipocyte lineages. We show here...
9.
10.
Scime A, Soleimani V, Bentzinger C, Gillespie M, Le Grand F, Grenier G, et al.
J Cell Biol
. 2010 Aug;
190(4):651-62.
PMID: 20713602
Mice lacking p107 exhibit a white adipose deficiency yet do not manifest the metabolic changes typical for lipodystrophy, and instead exhibit low levels of serum triglycerides and a normal liver...