Anthony S Wierzbicki
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Explore the profile of Anthony S Wierzbicki including associated specialties, affiliations and a list of published articles.
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212
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2464
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Recent Articles
1.
Wierzbicki A
Expert Opin Pharmacother
. 2024 Dec;
26(2):157-165.
PMID: 39709627
Introduction: Lipid-lowering therapies are well established for the treatment of cardiovascular disease (CVD). Historically monotherapy studies have been performed, but the introduction of statins has led to these drugs being...
2.
Wierzbicki A
Med
. 2024 Dec;
5(12):1446-1448.
PMID: 39674167
The PALISADE trial extended the data available for inhibition of apolipoprotein (apo) C3 inhibition for treating severe hypertriglyceridemia. 75 patients with persistent chylomicronemia were allocated to 2 doses of plozasiran...
3.
Zoungas S, Moran C, Curtis A, Spark S, Flanagan Z, Beilin L, et al.
J Am Heart Assoc
. 2024 Nov;
13(22):e036357.
PMID: 39548016
Background: The risk-benefit balance of statin use in healthy older people is uncertain. We describe the baseline characteristics of the STAREE (Statins in Reducing Events in the Elderly) trial, which...
4.
Bashir B, Downie P, Forrester N, Wierzbicki A, Dawson C, Jones A, et al.
Arterioscler Thromb Vasc Biol
. 2024 Sep;
44(11):2334-2346.
PMID: 39234690
Background: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to study the genotype distribution of FCS-causing genes in the United Kingdom, genotype-phenotype correlation, and clinical...
5.
Wanninayake S, Ochoa-Ferraro A, Patel K, Ramachandran R, Wierzbicki A, Dawson C
JIMD Rep
. 2024 Jul;
65(4):249-254.
PMID: 38974616
Familial chylomicronemia syndrome (FCS) is a rare inherited disorder characterized by severe hypertriglyceridemia, posing a heightened risk of acute pancreatitis. Recently, Volanesorsen, an APOC3 antisense oligonucleotide, gained approval for FCS...
6.
Jakubowska A, Al Hasani W, Williams J, MacMahon Z, Balbas B, Crook M, et al.
Curr Med Res Opin
. 2024 Apr;
:1-6.
PMID: 38616695
Objective: Novel lipid-lowering therapies are being introduced. Few studies exist of the real-world effectiveness of adenosine-tri-phosphate citrate lyase inhibition with bempedoic acid. Methods: This study audited bempedoic acid therapy in...
7.
Bashir B, Kwok S, Wierzbicki A, Jones A, Dawson C, Downie P, et al.
Atherosclerosis
. 2024 Mar;
391:117476.
PMID: 38447437
Background And Aims: Prognosis and management differ between familial chylomicronaemia syndrome (FCS), a rare autosomal recessive disorder, and multifactorial chylomicronaemia syndrome (MCS) or severe mixed hyperlipidaemia. A clinical scoring tool...
8.
Preventive cardiology for the aging population: how can we better design clinical trials of statins?
Wierzbicki A
Expert Rev Cardiovasc Ther
. 2024 Jan;
22(1-3):13-18.
PMID: 38258576
Introduction: Older adults form a fast-increasing proportion of the world population. However, gains in increasing quantity of life have not been accompanied by similar gains in quality of life. Older...
9.
Molokhia M, Wierzbicki A, Williams H, Kirubakaran A, Devani R, Durbaba S, et al.
Atherosclerosis
. 2023 Dec;
388:117353.
PMID: 38157708
Background And Aims: Differences in the perceived prevalence of familial hypercholesterolemia (FH) by ethnicity are unclear. In this study, we aimed to assess the prevalence, determinants and management of diagnostically-coded...
10.
Ayoub A, Akyea R, LEsperance V, Ayis S, Parmar D, Durbaba S, et al.
Lancet
. 2023 Nov;
402 Suppl 1:S26.
PMID: 37997066
Background: Primary dyslipidaemias, including familial hypercholesterolaemia, are underdiagnosed genetic disorders that substantially increase risk for premature coronary artery disease in adults. Early identification of primary dyslipidaemias via lipid clinic referral...