Anthony Long
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Explore the profile of Anthony Long including associated specialties, affiliations and a list of published articles.
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18
Citations
334
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Recent Articles
1.
Escher S, Aguayo-Orozco A, Benfenati E, Bitsch A, Braunbeck T, Brotzmann K, et al.
Toxicol In Vitro
. 2021 Nov;
79:105269.
PMID: 34757180
Read-across approaches often remain inconclusive as they do not provide sufficient evidence on a common mode of action across the category members. This read-across case study on thirteen, structurally similar,...
2.
Linder R, Majumder A, Chakraborty M, Long A
Genetics
. 2020 Apr;
215(2):323-342.
PMID: 32241804
Advanced-generation multiparent populations (MPPs) are a valuable tool for dissecting complex traits, having more power than genome-wide association studies to detect rare variants and higher resolution than F linkage mapping....
3.
Montefiori M, Lyngholm-Kjaerby C, Long A, Olsen L, Jorgensen F
Comput Struct Biotechnol J
. 2019 Apr;
17:345-351.
PMID: 30949305
Aldehyde Oxidase (AO) is an enzyme involved in the metabolism of aldehydes and -containing heterocyclic compounds. Many drug compounds contain heterocyclic moieties, and AO metabolism has lead to failure of...
4.
Li J, Vazquez-Garcia I, Persson K, Gonzalez A, Yue J, Barre B, et al.
Mol Biol Evol
. 2019 Jan;
36(4):691-708.
PMID: 30657986
Pre-existing and de novo genetic variants can both drive adaptation to environmental changes, but their relative contributions and interplay remain poorly understood. Here we investigated the evolutionary dynamics in drug-treated...
5.
Ponting D, Murray E, Long A
Drug Discov Today
. 2017 Jan;
22(7):970-975.
PMID: 28088443
How confident can we be in the assignment of metabolite structures? Are the analytical techniques used sufficient to support hypotheses about what is being formed? In this Feature, we discuss...
6.
Judson P, Long A, Murray E, Patel M
Mol Inform
. 2016 Aug;
34(5):284-91.
PMID: 27490274
A previous paper1 described new metrics, veracity and utility, for assessing the performance of toxicity prediction systems that report confidence in their predictions. Assessing the performance of systems that predict...
7.
Long A, Rydberg P
Mol Inform
. 2016 Aug;
32(1):81-6.
PMID: 27481025
To enhance the discrimination rate for methods applying structural alerts and biotransformation rules in the prediction of toxicity and drug metabolism we have developed a set of novel fragment based...
8.
Long A, Liti G, Luptak A, Tenaillon O
Nat Rev Genet
. 2015 Sep;
16(10):567-82.
PMID: 26347030
Evolve and resequence (E&R) experiments use experimental evolution to adapt populations to a novel environment, then next-generation sequencing to analyse genetic changes. They enable molecular evolution to be monitored in...
9.
Long A
Drug Discov Today Technol
. 2013 Sep;
10(1):e147-53.
PMID: 24050244
Drug metabolism in silico is briefly discussed in terms of the importance of understanding the mechanistic basis of drug molecule biotransformation in vivo and its consequences in terms of changes...
10.
Driscoll M, Long A
Healthc Financ Manage
. 2012 Apr;
66(4):90-4.
PMID: 22523893
After a hospital acquires a physician practice, relations can become strained between the parties in any of four areas: Governance and decision making. Technology. Payment structures. Emotional factors related to...