Ansgar Philippsen
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Explore the profile of Ansgar Philippsen including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
1.
Dror R, Mildorf T, Hilger D, Manglik A, Borhani D, Arlow D, et al.
Science
. 2015 Jun;
348(6241):1361-5.
PMID: 26089515
G protein-coupled receptors (GPCRs) relay diverse extracellular signals into cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying this quintessential molecular signaling event has remained unclear....
2.
Schenk A, Philippsen A, Engel A, Walz T
J Struct Biol
. 2013 Mar;
182(2):173-85.
PMID: 23500887
Electron crystallography of two-dimensional crystals allows the structural study of membrane proteins in their native environment, the lipid bilayer. Determining the structure of a membrane protein at near-atomic resolution by...
3.
Mariani V, Schenk A, Philippsen A, Engel A
J Struct Biol
. 2011 Mar;
174(2):259-68.
PMID: 21362479
The phase contrast theory describes the transfer of information from a weak-phase object to the image plane of a transmission electron microscope. For a tilted sample where the distance from...
4.
Biasini M, Mariani V, Haas J, Scheuber S, Schenk A, Schwede T, et al.
Bioinformatics
. 2010 Aug;
26(20):2626-8.
PMID: 20733063
Motivation: Developers of new methods in computational structural biology are often hampered in their research by incompatible software tools and non-standardized data formats. To address this problem, we have developed...
5.
Signorell G, Chami M, Condemine G, Schenk A, Philippsen A, Engel A, et al.
J Struct Biol
. 2007 Oct;
160(3):395-403.
PMID: 17919922
We present the projection structures of the three outer membrane porins KdgM and KdgN from Erwinia chrysanthemi and NanC from Escherichia coli, based on 2D electron crystallography. A wide screening...
6.
Broz P, Mueller C, Muller S, Philippsen A, Sorg I, Engel A, et al.
Mol Microbiol
. 2007 Aug;
65(5):1311-20.
PMID: 17697254
By quantitative immunoblot analyses and scanning transmission electron microscopy (STEM), we determined that the needle of the Yersinia enterocolitica E40 injectisome consists of 139 +/- 19 YscF subunits and that...
7.
Philippsen A, Engel H, Engel A
Ultramicroscopy
. 2006 Sep;
107(2-3):202-12.
PMID: 16989948
A theoretical description of the contrast-imaging function is derived for tilted specimens that exhibit weak-phase object characteristics. We show that the tilted contrast-imaging function (TCIF) is a linear transformation, which...
8.
Philippsen A, Schenk A, Signorell G, Mariani V, Berneche S, Engel A
J Struct Biol
. 2006 Aug;
157(1):28-37.
PMID: 16919967
We present the Image Processing Library and Toolbox, IPLT, in the context of a collaborative electron microscopy processing effort, which has driven the evolution of our software architecture over the...
9.
Eifler N, Vetsch M, Gregorini M, Ringler P, Chami M, Philippsen A, et al.
EMBO J
. 2006 May;
25(11):2652-61.
PMID: 16688219
ClyA is a pore-forming toxin from virulent Escherichia coli and Salmonella enterica strains. Here, we show that the intrinsic hemolytic activity of ClyA is independent of its redox state, and...
10.
Fotiadis D, Jastrzebska B, Philippsen A, Muller D, Palczewski K, Engel A
Curr Opin Struct Biol
. 2006 Mar;
16(2):252-9.
PMID: 16567090
G-protein-coupled receptors (GPCRs) participate in virtually all physiological processes. They constitute the largest and most structurally conserved family of signaling molecules. Several class C GPCRs have been shown to exist...