Annina Denoth-Lippuner
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Explore the profile of Annina Denoth-Lippuner including associated specialties, affiliations and a list of published articles.
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11
Citations
332
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Recent Articles
1.
Muhar M, Farnung J, Cernakova M, Hofmann R, Henneberg L, Pfleiderer M, et al.
Nature
. 2025 Jan;
638(8050):519-527.
PMID: 39880951
During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins...
2.
Royall L, Machado D, Jessberger S, Denoth-Lippuner A
Elife
. 2023 Oct;
12.
PMID: 37882444
During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional...
3.
Denoth-Lippuner A, Royall L, Gonzalez-Bohorquez D, Machado D, Jessberger S
STAR Protoc
. 2022 Feb;
3(1):101129.
PMID: 35118433
Pluripotent stem cell-derived human cortical organoids allow for the analysis of stem cell behavior and neurogenesis in neural tissues. Delivery of plasmid DNA into organoids permits visualization of individual cells,...
4.
Denoth-Lippuner A, Jaeger B, Liang T, Royall L, Chie S, Buthey K, et al.
Cell Stem Cell
. 2021 Sep;
28(11):2020-2034.e12.
PMID: 34525348
The division potential of individual stem cells and the molecular consequences of successive rounds of proliferation remain largely unknown. Here, we developed an inducible cell division counter (iCOUNT) that reports...
5.
Denoth-Lippuner A, Jessberger S
Nat Rev Neurosci
. 2021 Feb;
22(4):223-236.
PMID: 33633402
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain. Adult-born neurons shape brain function, and endogenous NSCs could potentially be harnessed for brain repair. In this...
6.
Jaeger B, Yanguez E, Gesuita L, Denoth-Lippuner A, Kruse M, Karayannis T, et al.
STAR Protoc
. 2020 Oct;
1(2):100081.
PMID: 33000004
This protocol presents a plate-based workflow to perform RNA sequencing analysis of single cells/nuclei using Smart-seq2. We describe (1) the dissociation procedures for cell/nucleus isolation from the mouse brain and...
7.
Denoth-Lippuner A, Jessberger S
FEBS Lett
. 2019 Jun;
593(23):3381-3392.
PMID: 31197818
Aging leads to changes on an organismal but also cellular level. However, the exact mechanisms of cellular aging in mammals remain poorly understood and the identity and functional role of...
8.
Kruitwagen T, Chymkowitch P, Denoth-Lippuner A, Enserink J, Barral Y
Cell
. 2018 Oct;
175(3):780-795.e15.
PMID: 30318142
During mitosis, chromatin condensation shapes chromosomes as separate, rigid, and compact sister chromatids to facilitate their segregation. Here, we show that, unlike wild-type yeast chromosomes, non-chromosomal DNA circles and chromosomes...
9.
Wang X, Le N, Denoth-Lippuner A, Barral Y, Kroschewski R
Proc Natl Acad Sci U S A
. 2016 Jun;
113(26):7177-82.
PMID: 27298340
Foreign DNA molecules and chromosomal fragments are generally eliminated from proliferating cells, but we know little about how mammalian cells prevent their propagation. Here, we show that dividing human and...
10.
Kruitwagen T, Denoth-Lippuner A, Wilkins B, Neumann H, Barral Y
Elife
. 2015 Nov;
4:e1039.
PMID: 26615018
The segregation of eukaryotic chromosomes during mitosis requires their extensive folding into units of manageable size for the mitotic spindle. Here, we report on how phosphorylation at serine 10 of...