Annika Asplund
Overview
Explore the profile of Annika Asplund including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
258
Followers
0
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Recent Articles
1.
Ghosheh N, Kuppers-Munther B, Asplund A, Andersson C, Bjorquist P, Andersson T, et al.
ACS Omega
. 2020 Mar;
5(10):4816-4827.
PMID: 32201767
Human pluripotent stem cell-derived hepatocytes (hPSC-HEP) display many properties of mature hepatocytes, including expression of important genes of the drug metabolizing machinery, glycogen storage, and production of multiple serum proteins....
2.
Holmgren G, Ulfenborg B, Asplund A, Toet K, Andersson C, Hammarstedt A, et al.
Int J Mol Sci
. 2020 Jan;
21(2).
PMID: 31940797
There is a strong anticipated future for human induced pluripotent stem cell-derived hepatocytes (hiPS-HEP), but so far, their use has been limited due to insufficient functionality. We investigated the potential...
3.
Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, et al.
J Hepatol
. 2017 Jul;
64(2):525-526.
PMID: 28743474
No abstract available.
4.
Ghosheh N, Kuppers-Munther B, Asplund A, Edsbagge J, Ulfenborg B, Andersson T, et al.
Physiol Genomics
. 2017 Jul;
49(8):430-446.
PMID: 28698227
Hepatocytes derived from human pluripotent stem cells (hPSC-HEP) have the potential to replace presently used hepatocyte sources applied in liver disease treatment and models of drug discovery and development. Established...
5.
Starokozhko V, Vatakuti S, Schievink B, Merema M, Asplund A, Synnergren J, et al.
Arch Toxicol
. 2016 Dec;
91(7):2711.
PMID: 27900403
No abstract available.
6.
Starokozhko V, Vatakuti S, Schievink B, Merema M, Asplund A, Synnergren J, et al.
Arch Toxicol
. 2016 Oct;
91(5):2079-2092.
PMID: 27717970
Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use...
7.
Ghosheh N, Olsson B, Edsbagge J, Kuppers-Munther B, Van Giezen M, Asplund A, et al.
Stem Cells Int
. 2016 Mar;
2016:8648356.
PMID: 26949401
Human pluripotent stem cells- (hPSCs-) derived hepatocytes have the potential to replace many hepatic models in drug discovery and provide a cell source for regenerative medicine applications. However, the generation...
8.
Asplund A, Pradip A, Van Giezen M, Aspegren A, Choukair H, Rehnstrom M, et al.
Stem Cell Rev Rep
. 2015 Sep;
12(1):90-104.
PMID: 26385115
Human hepatocytes display substantial functional inter-individual variation regarding drug metabolizing functions. In order to investigate if this diversity is mirrored in hepatocytes derived from different human pluripotent stem cell (hPSC)...
9.
Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, et al.
J Hepatol
. 2015 May;
63(4):934-42.
PMID: 26022688
Background & Aims: The differentiation of stem cells to hepatocyte-like cells (HLC) offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of HLC remains controversial....
10.
Sayin V, Khan O, Pehlivanoglu L, Staffas A, Ibrahim M, Asplund A, et al.
Circ Res
. 2014 Sep;
115(9):781-9.
PMID: 25212213
Rationale: Cell proliferation and cell cycle control mechanisms are thought to play central roles in the pathogenesis of atherosclerosis. The transcription factor Zinc finger protein 148 (Zfp148) was shown recently...