Annie D Cohen
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Explore the profile of Annie D Cohen including associated specialties, affiliations and a list of published articles.
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12
Citations
238
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Recent Articles
1.
Schworer E, Zammit M, Wang J, Handen B, Betthauser T, Laymon C, et al.
Lancet Neurol
. 2024 Nov;
23(12):1214-1224.
PMID: 39577922
Background: Adults with Down syndrome are at risk for Alzheimer's disease. Natural history cohort studies have characterised the progression of Alzheimer's disease biomarkers in people with Down syndrome, with a...
2.
Schworer E, Zammit M, Wang J, Handen B, Betthauser T, Laymon C, et al.
medRxiv
. 2024 Aug;
PMID: 39211859
Background: Adults with Down syndrome (DS) are at risk for Alzheimer's disease (AD). Recent natural history cohort studies have characterized AD biomarkers, with a focus on PET amyloid-beta (Aβ) and...
3.
Chen Y, Zeng X, Lee J, Sehrawat A, Lafferty T, Boslett J, et al.
medRxiv
. 2024 Mar;
PMID: 38496591
Introduction: The reliability of plasma Alzheimer's disease (AD) biomarkers can be compromised by protease-induced degradation. This limits the feasibility of conducting plasma biomarker studies in environments that lack the capacity...
4.
Zammit M, Betthauser T, McVea A, Laymon C, Tudorascu D, Johnson S, et al.
Alzheimers Dement
. 2023 Aug;
20(1):388-398.
PMID: 37641577
Introduction: Almost all individuals with Down syndrome (DS) will develop neuropathological features of Alzheimer's disease (AD). Understanding AD biomarker trajectories is necessary for DS-specific clinical interventions and interpretation of drug-related...
5.
Tissot C, Servaes S, Lussier F, Ferrari-Souza J, Therriault J, Ferreira P, et al.
J Nucl Med
. 2022 Nov;
64(3):452-459.
PMID: 36396455
6-(fluoro-F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([F]MK6240) tau PET tracer quantifies the brain tau neurofibrillary tangle load in Alzheimer disease. The aims of our study were to test the stability of common reference region estimates...
6.
Nadkarni N, Tudorascu D, Campbell E, Snitz B, Cohen A, Halligan E, et al.
J Gerontol A Biol Sci Med Sci
. 2019 Apr;
74(11):1753-1760.
PMID: 30957843
Background: We estimated the prevalence and incidence of amyloid-β deposition (A), small-vessel disease (V), and neurodegeneration (N) biomarker positivity in community-dwelling cognitively normal individuals (CN). We determined the longitudinal association...
7.
Mihaila I, Handen B, Christian B, Lao P, Cody K, Klunk W, et al.
Dev Neurobiol
. 2019 Mar;
79(7):738-749.
PMID: 30912871
The present study provided an investigation of associations between leisure activity and early Alzheimer's disease neuropathology (i.e., brain β-amyloid) and episodic memory in a sample of 65 adults with Down...
8.
Lao P, Handen B, Betthauser T, Cody K, Cohen A, Tudorascu D, et al.
Brain Imaging Behav
. 2018 May;
13(2):345-353.
PMID: 29752653
The focus of Alzheimer's disease (AD) neuroimaging research has shifted towards an investigation of the earliest stages of AD pathogenesis, which manifests in every young adult with Down syndrome (DS;...
9.
Lao P, Handen B, Betthauser T, Mihaila I, Hartley S, Cohen A, et al.
J Alzheimers Dis
. 2017 Dec;
61(2):631-644.
PMID: 29254096
Background: The Down syndrome (DS) population is genetically predisposed to amyloid-β protein precursor overproduction and Alzheimer's disease (AD). Objective: The temporal ordering and spatial association between amyloid-β, glucose metabolism, and...
10.
Lao P, Handen B, Betthauser T, Mihaila I, Hartley S, Cohen A, et al.
Alzheimers Dement (Amst)
. 2017 Jun;
9:1-9.
PMID: 28603769
Introduction: Down syndrome (DS) arises from a triplication of chromosome 21, causing overproduction of the amyloid precursor protein and predisposes individuals to early Alzheimer's disease (AD). Methods: Fifty-two nondemented adults...