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Annette Tschuschner

Explore the profile of Annette Tschuschner including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 229
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Recent Articles
1.
Muller H, Strassmann J, Baier A, von Bulow V, Stettler F, Hagen M, et al.
Cells . 2024 Oct; 13(19. PMID: 39404406
Schistosomiasis affects over 250 million people worldwide, with the highest prevalence at the age of 10-14 years. The influence of the host's age on the severity of liver damage is...
2.
Harle L, von Bulow V, Knedla L, Stettler F, Muller H, Zahner D, et al.
Sci Rep . 2023 Nov; 13(1):20390. PMID: 37990129
Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide. The transcription factor c-Jun, which is induced in S. mansoni infection-associated liver disease, can promote hepatocyte survival but...
3.
von Bulow V, Schneider M, Dreizler D, Russ L, Baier A, Buss N, et al.
Cell Mol Gastroenterol Hepatol . 2023 Sep; 17(1):107-117. PMID: 37696392
Background & Aims: Schistosomiasis is one of the most prominent parasite-induced infectious diseases, affecting more than 250 million people. Schistosoma mansoni causes metabolic exhaustion and a strong redox imbalance in...
4.
Weglage J, Wolters F, Hehr L, Lichtenberger J, Wulz C, Hempel F, et al.
Sci Rep . 2020 Dec; 10(1):22373. PMID: 33361772
Schistosomiasis (bilharzia) is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, with considerable morbidity in parts of the Middle East, South America, Southeast Asia, in sub-Saharan...
5.
Roderfeld M, Padem S, Lichtenberger J, Quack T, Weiskirchen R, Longerich T, et al.
Hepatology . 2018 Jul; 72(2):626-641. PMID: 30053321
Clinical data have provided evidence that schistosomiasis can promote hepatocellular carcinogenesis. c-Jun and STAT3 are critical regulators of liver cancer development and progression. The aim of the present study was...
6.
Zahner D, Glimm H, Matono T, Churin Y, Herebian D, Mayatepek E, et al.
Oncotarget . 2017 Sep; 8(32):52560-52570. PMID: 28881751
Conclusion: Cholestasis-induced STAT3- and JNK-pathways may predispose HBsAg-associated tumorigenesis. Since STAT3- and JNK-activation are well characterized critical regulators for tumor promotion, the potentiation of their activation in hybrids suggests an...
7.
Wernicke A, Churin Y, Sheridan D, Windhorst A, Tschuschner A, Gattenlohner S, et al.
Oncotarget . 2016 Oct; 7(45):73552-73557. PMID: 27716617
An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in...
8.
Graumann F, Churin Y, Tschuschner A, Reifenberg K, Glebe D, Roderfeld M, et al.
PLoS One . 2015 Dec; 10(12):e0146099. PMID: 26717563
Objective: The Hepatitis B virus genome persists in the nucleus of virus infected hepatocytes where it serves as template for viral mRNA synthesis. Epigenetic modifications, including methylation of the CpG...
9.
Koc A, Bargen I, Suwandi A, Roderfeld M, Tschuschner A, Rath T, et al.
PLoS One . 2014 Apr; 9(4):e94624. PMID: 24728142
Mycobacterium avium ssp. paratuberculosis (MAP) is the cause of Johne's disease, an inflammatory bowel disorder of ruminants. Due to the similar pathology, MAP was also suggested to cause Crohn's disease...
10.
Rath T, Stockle J, Roderfeld M, Tschuschner A, Graf J, Roeb E
Oncol Lett . 2012 Aug; 2(3):483-488. PMID: 22866107
Matrix metalloproteinases (MMPs) are associated with cancer cell invasion and metastasis, and are currently the most prominent proteases associated with tumorigenesis. In particular, abundant expression of MMP-13 in colorectal cancer...