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Anne Marie ODonnell

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Articles 27
Citations 150
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Recent Articles
1.
Cascio S, ODonnell A
Pediatr Surg Int . 2022 Dec; 39(1):50. PMID: 36520301
The National Children's Research Centre (NCRC), the single largest paediatric research centre in Ireland, has been in existence for over 50 years and is located on the grounds of the...
2.
ODonnell A
Pediatr Surg Int . 2022 Dec; 39(1):33. PMID: 36460933
Hirschsprung's disease (HD) is a congenital condition characterised by aganglionosis in the distal bowel. Over the years, at the National Children's Research Centre (NCRC), HD has been one of the...
3.
Tomuschat C, ODonnell A, Coyle D, Puri P
J Pediatr Surg . 2019 Dec; 55(8):1488-1494. PMID: 31859043
Purpose: The pathophysiology of Hirschsprung's associated enterocolitis (HAEC) is not understood. Abnormal intestinal motility and altered intestinal epithelial barrier function have been suggested to play a key role in the...
4.
ODonnell A, Nakamura H, Puri P
Eur J Pediatr Surg . 2019 Nov; 30(1):59-63. PMID: 31707728
Introduction:  "Tuft" cells, also known as brush or caveolated cells, are characteristically fusiform shaped, with a distinct apical "tuft" of microvilli extending into the lumen. Double cortin-like kinase 1 (DCLK1)...
5.
Nakamura H, ODonnell A, Tomuschat C, Coyle D, Puri P
Pediatr Surg Int . 2019 Jul; 35(9):929-934. PMID: 31256294
Background/purpose: The pathogenesis of Hirschsprung's disease-associated enterocolitis (HAEC) is unclear. Caveolin-1 (Cav-1) regulates the functions of different nitric oxide synthase (NOS) isoforms, which play critical roles in inflammation and intestinal...
6.
Coyle D, ODonnell A, Tomuschat C, Gillick J, Puri P
J Pediatr Surg . 2019 May; 54(11):2318-2324. PMID: 31079866
Background: Retained transition zone is a leading cause of obstructive symptoms after pull-through operation in Hirschsprung's disease. Objective: We aimed to evaluate the extent of the histological transition zone in...
7.
Nakamura H, ODonnell A, Marayati N, Tomuschat C, Coyle D, Puri P
Pediatr Surg Int . 2018 Nov; 35(1):15-20. PMID: 30386901
Aim Of The Study: The pathogenesis of Hirschsprung's disease-associated enterocolitis (HAEC) is poorly understood. Inflammasomes are a large family of multiprotein complexes that act to mediate host immune responses to...
8.
ODonnell A, Nakamura H, Tomuschat C, Marayati N, Puri P
Pediatr Surg Int . 2018 Nov; 35(2):193-197. PMID: 30386900
Purpose: Voltage-gated potassium ion channels have long been implicated in gastrointestinal motility. Recent studies have highlighted the role of voltage-gated channel subfamily G member 3 (KCNG3) and 4 (KCNG4) genes...
9.
ODonnell A, Nakamura H, Tomuschat C, Marayati N, Puri P
Pediatr Surg Int . 2018 Nov; 35(1):9-14. PMID: 30386899
Purpose: Smooth muscle cells are electrically coupled to ICC and PDGFRα cells, to regulate smooth muscle contraction. Recent studies have reported that the voltage-gated sodium channel type 1β (Scn1b), and...
10.
Nakamura H, ODonnell A, Puri P
Pediatr Surg Int . 2018 Nov; 35(2):175-180. PMID: 30386895
Background/purpose: Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare congenital and generally fatal cause of functional intestinal obstruction in the newborn. The cause of this syndrome is unknown. Familial...