Anna Lyakisheva
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Explore the profile of Anna Lyakisheva including associated specialties, affiliations and a list of published articles.
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11
Citations
144
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Recent Articles
1.
Ghazi Vakili M, Gorgulla C, Snider J, Nigam A, Bezrukov D, Varoli D, et al.
Nat Biotechnol
. 2025 Jan;
PMID: 39843581
We introduce a quantum-classical generative model for small-molecule design, specifically targeting KRAS inhibitors for cancer therapy. We apply the method to design, select and synthesize 15 proposed molecules that could...
2.
Yao Z, Kim J, Geng B, Chen J, Wong V, Lyakisheva A, et al.
Mol Syst Biol
. 2024 Dec;
21(2):107-125.
PMID: 39668253
Elucidation of protein-protein interactions (PPIs) represents one of the most important methods in biomedical research. Recently, PPIs have started to be exploited for drug discovery purposes and have thus attracted...
3.
Phadnis V, Snider J, Varadharajan V, Ramachandiran I, Deik A, Lai Z, et al.
Cell Rep
. 2023 Sep;
42(9):113023.
PMID: 37691145
Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid...
4.
Kim S, Yao Z, Marsh M, Eckert D, Kay M, Lyakisheva A, et al.
Nat Commun
. 2022 Jul;
13(1):3716.
PMID: 35778399
The COVID-19 pandemic triggered the development of numerous diagnostic tools to monitor infection and to determine immune response. Although assays to measure binding antibodies against SARS-CoV-2 are widely available, more...
5.
Lim S, Snider J, Birimberg-Schwartz L, Ip W, Serralha J, Botelho H, et al.
Mol Syst Biol
. 2022 Feb;
18(2):e10629.
PMID: 35156780
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and bicarbonate channel in secretory epithelia with a critical role in maintaining fluid homeostasis. Mutations in CFTR are associated with Cystic...
6.
Grozavu I, Stuart S, Lyakisheva A, Yao Z, Pathmanathan S, Ohh M, et al.
J Mol Biol
. 2021 Dec;
434(2):167392.
PMID: 34896362
KRAS is one of the most frequently mutated oncogenes in human cancers. Despite nearly 40 years of research, KRAS remains largely undruggable, in part due to an incomplete understanding of...
7.
Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sanchez-Osuna M, et al.
J Mol Biol
. 2021 Oct;
433(23):167294.
PMID: 34662547
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are...
8.
Pathmanathan S, Grozavu I, Lyakisheva A, Stagljar I
Curr Opin Chem Biol
. 2021 Aug;
66:102079.
PMID: 34426091
In recent years, the research community has, with comprehensive systems biology approaches and related technologies, gained insight into the vast complexity of numerous cancers. These approaches allow an in-depth exploration...
9.
Saraon P, Pathmanathan S, Snider J, Lyakisheva A, Wong V, Stagljar I
Oncogene
. 2021 Jun;
40(24):4079-4093.
PMID: 34079087
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK dysregulation have been identified,...
10.
Yao Z, Aboualizadeh F, Kroll J, Akula I, Snider J, Lyakisheva A, et al.
Nat Commun
. 2020 May;
11(1):2440.
PMID: 32415080
Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait...