Anna Laddach
Overview
Explore the profile of Anna Laddach including associated specialties, affiliations and a list of published articles.
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10
Citations
149
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Recent Articles
1.
Laddach A, Pachnis V, Shapiro M
NAR Genom Bioinform
. 2024 Oct;
6(4):lqae139.
PMID: 39380945
Differentiation of multipotential progenitor cells is a key process in the development of any multi-cellular organism and often continues throughout its life. It is often assumed that a bi-potential progenitor...
2.
Laddach A, Chng S, Lasrado R, Progatzky F, Shapiro M, Erickson A, et al.
Nat Commun
. 2023 Sep;
14(1):5904.
PMID: 37737269
Glial cells have been proposed as a source of neural progenitors, but the mechanisms underpinning the neurogenic potential of adult glia are not known. Using single cell transcriptomic profiling, we...
3.
Cujba A, Alvarez-Fallas M, Pedraza-Arevalo S, Laddach A, Shepherd M, Hattersley A, et al.
Cell Rep
. 2022 Mar;
38(9):110425.
PMID: 35235779
The HNF1α truncation is the most common mutation associated with maturity-onset diabetes of the young 3 (MODY3). Although shown to impair HNF1α signaling, the mechanism by which HNF1α causes MODY3...
4.
Vickers A, Tewary M, Laddach A, Poletti M, Salameti V, Fraternali F, et al.
Stem Cell Reports
. 2021 Oct;
16(11):2628-2641.
PMID: 34678211
Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors is a powerful tool for uncovering the relationship between genetic variants and cellular behavior. We previously identified...
5.
Progatzky F, Shapiro M, Chng S, Garcia-Cassani B, Classon C, Sevgi S, et al.
Nature
. 2021 Oct;
599(7883):125-130.
PMID: 34671159
Tissue maintenance and repair depend on the integrated activity of multiple cell types. Whereas the contributions of epithelial, immune and stromal cells in intestinal tissue integrity are well understood, the...
6.
Laddach A, Ng J, Fraternali F
PLoS Biol
. 2021 Apr;
19(4):e3001207.
PMID: 33909605
Missense variants are present amongst the healthy population, but some of them are causative of human diseases. A classification of variants associated with "healthy" or "diseased" states is therefore not...
7.
Chung S, Ng J, Laddach A, Thomas N, Fraternali F
NAR Genom Bioinform
. 2021 Mar;
3(1):lqab010.
PMID: 33709075
Direct drug targeting of mutated proteins in cancer is not always possible and efficacy can be nullified by compensating protein-protein interactions (PPIs). Here, we establish an pipeline to identify specific...
8.
Vigilante A, Laddach A, Moens N, Meleckyte R, Leha A, Ghahramani A, et al.
Cell Rep
. 2019 Feb;
26(8):2078-2087.e3.
PMID: 30784590
Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate...
9.
Laddach A, Ng J, Chung S, Fraternali F
Curr Opin Struct Biol
. 2018 Jan;
50:82-90.
PMID: 29306755
We review recent progress in the mapping of genetic variants to proteins, in the context of their interactions, as measured from experiments and/or computational predictions. Such variants can impact on...
10.
Laddach A, Gautel M, Fraternali F
Bioinformatics
. 2017 Oct;
33(21):3482-3485.
PMID: 29077808
Summary: Large numbers of rare and unique titin missense variants have been discovered in both healthy and disease cohorts, thus the correct classification of variants as pathogenic or non-pathogenic has...