Anna Dorogin
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Explore the profile of Anna Dorogin including associated specialties, affiliations and a list of published articles.
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16
Citations
416
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Recent Articles
1.
Khader N, Shchuka V, Dorogin A, Shynlova O, Mitchell J
PLoS One
. 2024 Apr;
19(4):e0297847.
PMID: 38635533
The uterine muscular layer, or myometrium, undergoes profound changes in global gene expression during its progression from a quiescent state during pregnancy to a contractile state at the onset of...
2.
Shchuka V, Khader N, Dorogin A, Shynlova O, Mitchell J
PLoS One
. 2023 Jan;
18(1):e0271081.
PMID: 36595497
Spontaneous uterine contractions are initiated when smooth muscle cells (SMCs) within the uterine muscle, or myometrium, transition from a functionally dormant to an actively contractile phenotype at the end of...
3.
Shynlova O, Nadeem L, Dorogin A, Mesiano S, Lye S
Am J Obstet Gynecol
. 2021 Aug;
226(2):249.e1-249.e21.
PMID: 34418351
Background: Progesterone, acting via its nuclear receptors called progesterone receptors, promotes myometrial relaxation during pregnancy, and suspension of this activity triggers labor. We previously found that 20α-hydroxysteroid dehydrogenase causes a...
4.
Nadeem L, Balendran R, Dorogin A, Mesiano S, Shynlova O, Lye S
J Cell Mol Med
. 2021 Jun;
25(14):6773-6785.
PMID: 34114342
Metabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α-HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic...
5.
Chatterjee A, Saghian R, Dorogin A, Cahill L, Sled J, Lye S, et al.
Sci Rep
. 2021 Mar;
11(1):4903.
PMID: 33649420
The cervix is responsible for maintaining pregnancy, and its timely remodeling is essential for the proper delivery of a baby. Cervical insufficiency, or "weakness", may lead to preterm birth, which...
6.
Shchuka V, Abatti L, Hou H, Khader N, Dorogin A, Wilson M, et al.
PLoS Biol
. 2020 Jul;
18(7):e3000710.
PMID: 32667910
During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known....
7.
Nadeem L, Farine T, Dorogin A, Matysiak-Zablocki E, Shynlova O, Lye S
J Cell Mol Med
. 2017 Sep;
22(1):452-471.
PMID: 28945005
Preterm labour (PTL) is a leading cause of perinatal mortality and postnatal morbidity. Contractions of the uterine muscle (myometrium) that determine the onset of labour depend on the expression of...
8.
Shynlova O, Dorogin A, Li Y, Lye S
J Cell Mol Med
. 2014 Jun;
18(9):1816-29.
PMID: 24894878
Preterm birth (PTB) is the single most important cause of perinatal and infant mortality worldwide. Maternal infection can result in PTB. We investigated the ability of a Broad Spectrum Chemokine...
9.
Shynlova O, Nedd-Roderique T, Li Y, Dorogin A, Nguyen T, Lye S
J Cell Mol Med
. 2013 Feb;
17(2):311-24.
PMID: 23379349
Leucocyte infiltration in the decidua (maternal-foetal interface) before, during and after term (TL) and preterm labour (PTL) was studied in mouse. We also investigated the mechanism of peripheral leucocyte recruitment...
10.
Shynlova O, Nedd-Roderique T, Li Y, Dorogin A, Lye S
J Cell Mol Med
. 2012 Dec;
17(1):90-102.
PMID: 23205502
This study aimed to determine the mechanism of uterine activation during labour, both term (TL) and preterm (PTL). We hypothesized that the peripheral leucocytes are recruited to uterine tissues by...