Anna-Dorothea Gorki
Overview
Explore the profile of Anna-Dorothea Gorki including associated specialties, affiliations and a list of published articles.
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12
Citations
536
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Recent Articles
1.
Fortelny N, Farlik M, Fife V, Gorki A, Lassnig C, Maurer B, et al.
Nat Immunol
. 2024 Apr;
25(5):847-859.
PMID: 38658806
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is...
2.
Wali L, Karbiener M, Chou S, Kovtunyk V, Adonyi A, Gosler I, et al.
J Virus Erad
. 2022 Dec;
8(4):100305.
PMID: 36514716
Rhinoviruses (RVs) and coronaviruses (CoVs) upregulate host cell metabolic pathways such as glycolysis to meet their bioenergetic demands for rapid multiplication. Using the glycolysis inhibitor 2-deoxy-d-glucose (2-DG), we assessed the...
3.
Schrottmaier W, Kral-Pointner J, Salzmann M, Mussbacher M, Schmuckenschlager A, Pirabe A, et al.
Cell Rep
. 2022 Nov;
41(6):111614.
PMID: 36351402
Phosphatidylinositol 3-kinase catalytic subunit p110β is involved in tumorigenesis and hemostasis. However, it remains unclear if p110β also regulates platelet-mediated immune responses, which could have important consequences for immune modulation...
4.
Gawish R, Maier B, Obermayer G, Watzenboeck M, Gorki A, Quattrone F, et al.
Elife
. 2022 Sep;
11.
PMID: 36178806
Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options to prevent sepsis-associated immunopathology remain scarce. Here, we established a mouse model...
5.
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling
Zahalka S, Starkl P, Watzenboeck M, Farhat A, Radhouani M, Deckert F, et al.
Mucosal Immunol
. 2022 Jul;
15(5):896-907.
PMID: 35856089
Environmental microbial triggers shape the development and functionality of the immune system. Alveolar macrophages (AMs), tissue-resident macrophages of the lungs, are in constant and direct contact with inhaled particles and...
6.
Gorki A, Symmank D, Zahalka S, Lakovits K, Hladik A, Langer B, et al.
Am J Respir Cell Mol Biol
. 2021 Sep;
66(1):64-75.
PMID: 34586974
Tissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models are still limited. Here, we propose a novel culture model...
7.
Watzenboeck M, Gorki A, Quattrone F, Gawish R, Schwarz S, Lambers C, et al.
Eur Respir J
. 2021 Jul;
59(2).
PMID: 34244315
Rationale: Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases but bears the highest mortality rate among all solid organ transplantations due to chronic lung allograft...
8.
Watzenboeck M, Drobits B, Zahalka S, Gorki A, Farhat A, Quattrone F, et al.
PLoS Pathog
. 2021 Apr;
17(4):e1009487.
PMID: 33905460
Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference with bacterial iron uptake and exerts immunomodulatory functions in various...
9.
Sharif O, Brunner J, Korosec A, Martins R, Jais A, Snijder B, et al.
Diabetes
. 2021 Feb;
70(9):2042-2057.
PMID: 33627323
Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, worsening...
10.
Cohen M, Giladi A, Gorki A, Solodkin D, Zada M, Hladik A, et al.
Cell
. 2018 Oct;
175(4):1031-1044.e18.
PMID: 30318149
Lung development and function arises from the interactions between diverse cell types and lineages. Using single-cell RNA sequencing (RNA-seq), we characterize the cellular composition of the lung during development and...