Anja Lechner
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Explore the profile of Anja Lechner including associated specialties, affiliations and a list of published articles.
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13
Citations
243
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Recent Articles
1.
Schmidt D, Peterlik D, Reber S, Lechner A, Mannel D
PLoS One
. 2016 Jul;
11(7):e0159059.
PMID: 27391954
To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress....
2.
Reber S, Siebler P, Donner N, Morton J, Smith D, Kopelman J, et al.
Proc Natl Acad Sci U S A
. 2016 May;
113(22):E3130-9.
PMID: 27185913
The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show...
3.
Barth T, Schmidt D, Botteron C, Nguyen T, Ritter U, Mannel D, et al.
PLoS One
. 2012 Oct;
7(9):e44499.
PMID: 23028548
Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection. The...
4.
Moehrlen U, Lechner A, Baumel M, Dostert K, Rohrl J, Meuli M, et al.
Pediatr Surg Int
. 2012 Mar;
28(5):507-13.
PMID: 22426493
Purpose: There is evidence that open as well as minimally invasive abdominal surgery impair post-operative innate and acquired immune function. To compare the impact of these approaches as well as...
5.
Mohr A, Polz J, Martin E, Griessl S, Kammler A, Potschke C, et al.
Eur J Immunol
. 2011 Nov;
42(2):341-52.
PMID: 22105154
Immunosuppression, impaired cytokine production and high susceptibility to secondary infections are characteristic for septic patients, and for mice after induction of polymicrobial septic peritonitis by sublethal cecal ligation and puncture...
6.
Peters S, Grunwald N, Rummele P, Endlicher E, Lechner A, Neumann I, et al.
Stress
. 2011 Nov;
15(4):403-15.
PMID: 22044139
Patients with inflammatory bowel diseases (IBDs) have a higher risk of developing colorectal cancer (CRC) than the general population. Furthermore, chronic psychosocial stress increases the likelihood of developing IBD and...
7.
Schmidt D, Reber S, Botteron C, Barth T, Peterlik D, Uschold N, et al.
Brain Behav Immun
. 2010 May;
24(7):1097-104.
PMID: 20451603
Recent studies indicate that chronic psychosocial stress favors the development of generalized immune dysfunction. During stressor exposure neuroendocrine factors affect numbers and functionality of leukocytes. However, the exact mechanisms leading...
8.
Wiede F, Roomberg A, Cretney E, Lechner A, Fromm P, Wren L, et al.
J Leukoc Biol
. 2008 Oct;
85(1):108-16.
PMID: 18948547
The generalized lymphoproliferative disorder (gld) mouse strain is characterized by severe splenomegaly/lymphadenopathy, the production of autoimmune antibodies, and the appearance of CD4/CD8-negative T cells. An additional TNF deficiency of gld/gld...
9.
Potzl J, Botteron C, Tausch E, Pedre X, Mueller A, Mannel D, et al.
PLoS One
. 2008 Aug;
3(8):e2951.
PMID: 18698357
Background: The function of T helper cell subsets in vivo depends on their location, and one hallmark of T cell differentiation is the sequential regulation of migration-inducing chemokine receptor expression....
10.
Baumel M, Lechner A, Hehlgans T, Mannel D
J Leukoc Biol
. 2008 Apr;
84(1):162-9.
PMID: 18436580
TNF is a pleiotropic cytokine involved in a variety of inflammatory processes and immune responses. TNF effects are mediated via two distinct membrane receptors: TNFR1 and TNFR2. Investigations concerning regulation...