Anja-Katrin Bielinsky
Overview
Explore the profile of Anja-Katrin Bielinsky including associated specialties, affiliations and a list of published articles.
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56
Citations
1169
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Recent Articles
1.
Rogers C, Leung W, Baxley R, Kram R, Wang L, Buytendorp J, et al.
Biomolecules
. 2025 Jan;
15(1.
PMID: 39858544
RAD18 is a conserved eukaryotic E3 ubiquitin ligase that promotes genome stability through multiple pathways. One of these is gap-filling DNA synthesis at active replication forks and in post-replicative DNA....
2.
Rogers C, Leung W, Baxley R, Kram R, Wang L, Buytendorp J, et al.
bioRxiv
. 2024 Sep;
PMID: 39282285
Homologous recombination (HR) and translesion synthesis (TLS) promote gap-filling DNA synthesis to complete genome replication. One factor involved in both pathways is RAD18, an E3 ubiquitin ligase. Although RAD18's role...
3.
Rivard R, Chang Y, Ragland R, Thu Y, Kassab M, Mandal R, et al.
Cell Rep
. 2024 May;
43(5):114178.
PMID: 38703364
Innovative methods to retrieve proteins associated with actively replicating DNA have provided a glimpse into the molecular dynamics of replication fork stalling. We report that a combination of density-based replisome...
4.
Oram M, Baxley R, Simon E, Lin K, Chang Y, Wang L, et al.
DNA Repair (Amst)
. 2024 Feb;
135:103646.
PMID: 38340377
Eukaryotic genome stability is maintained by a complex and diverse set of molecular processes. One class of enzymes that promotes proper DNA repair, replication and cell cycle progression comprises small...
5.
Lin K, Chang Y, Billmann M, Ward H, Le K, Hassan A, et al.
Sci Rep
. 2024 Jan;
14(1):2508.
PMID: 38291084
Current approaches to define chemical-genetic interactions (CGIs) in human cell lines are resource-intensive. We designed a scalable chemical-genetic screening platform by generating a DNA damage response (DDR)-focused custom sgRNA library...
6.
Schmit M, Baxley R, Wang L, Hinderlie P, Kaufman M, Simon E, et al.
Open Biol
. 2024 Jan;
14(1):230407.
PMID: 38262603
Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient...
7.
Leung W, Baxley R, Traband E, Chang Y, Rogers C, Wang L, et al.
Cell Rep
. 2023 Dec;
42(12):113523.
PMID: 38060446
Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability....
8.
Chang Y, Lin K, Baxley R, Durrett W, Wang L, Stojkova O, et al.
Open Biol
. 2023 Aug;
13(8):230068.
PMID: 37607592
DNA replication requires precise regulation achieved through post-translational modifications, including ubiquitination and SUMOylation. These modifications are linked by the SUMO-targeted E3 ubiquitin ligases (STUbLs). Ring finger protein 4 (RNF4), one...
9.
Rogers C, Kram R, Lin K, Myers C, Sobeck A, Hendrickson E, et al.
Cell Rep
. 2023 Apr;
42(5):112428.
PMID: 37086407
Activation of the Fanconi anemia (FA) pathway after treatment with mitomycin C (MMC) is essential for preventing chromosome translocations termed "radials." When replication forks stall at MMC-induced interstrand crosslinks (ICLs),...
10.
Grange L, Reynolds J, Ullah F, Isidor B, Shearer R, Latypova X, et al.
Nat Commun
. 2022 Nov;
13(1):6664.
PMID: 36333305
Embryonic development is dictated by tight regulation of DNA replication, cell division and differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving rise to neurodevelopmental disease characterized...