Angus Harding
Overview
Explore the profile of Angus Harding including associated specialties, affiliations and a list of published articles.
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Snapshot
Snapshot
Articles
19
Citations
1055
Followers
0
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Related Specialties
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Recent Articles
1.
Tian T, Harding A
Cell Cycle
. 2014 Dec;
13(15):2379-90.
PMID: 25483189
Genetic and biochemical studies have revealed that the diversity of cell types and developmental patterns evident within the animal kingdom is generated by a handful of conserved, core modules. Core...
2.
Coward J, Harding A
Front Oncol
. 2014 Jun;
4:123.
PMID: 24904834
Tumor evolution presents a formidable obstacle that currently prevents the development of truly curative treatments for cancer. In this perspective, we advocate for the hypothesis that tumor cells with significantly...
3.
Donovan P, Cato K, Legaie R, Jayalath R, Olsson G, Hall B, et al.
Mol Biosyst
. 2014 Jan;
10(4):741-58.
PMID: 24448662
Here we report the identification of a proliferative, viable, and hyperdiploid tumor cell subpopulation present within Glioblastoma (GB) patient tumors. Using xenograft tumor models, we demonstrate that hyperdiploid cell populations...
4.
Day B, Stringer B, Al-Ejeh F, Ting M, Wilson J, Ensbey K, et al.
Cancer Cell
. 2013 Feb;
23(2):238-48.
PMID: 23410976
Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor tyrosine kinase EphA3 is...
5.
Lim Y, Roberts T, Day B, Harding A, Kozlov S, Kijas A, et al.
Mol Cancer Ther
. 2012 Jul;
11(9):1863-72.
PMID: 22772423
Glioblastoma multiforme (GBM) is the most common form of brain tumor with a poor prognosis and resistance to radiotherapy. Recent evidence suggests that glioma-initiating cells play a central role in...
6.
Whitacre J, Lin J, Harding A
Front Genet
. 2012 Feb;
3:5.
PMID: 22363338
Evolution is often characterized as a process involving incremental genetic changes that are slowly discovered and fixed in a population through genetic drift and selection. However, a growing body of...
7.
Deleyrolle L, Harding A, Cato K, Siebzehnrubl F, Rahman M, Azari H, et al.
Brain
. 2011 Apr;
134(Pt 5):1331-43.
PMID: 21515906
Individual tumour cells display diverse functional behaviours in terms of proliferation rate, cell-cell interactions, metastatic potential and sensitivity to therapy. Moreover, sequencing studies have demonstrated surprising levels of genetic diversity...
8.
Tian T, Olson S, Whitacre J, Harding A
Integr Biol (Camb)
. 2010 Oct;
3(1):17-30.
PMID: 20944865
Unless diagnosed early, many adult cancers remain incurable diseases. This is despite an intense global research effort to develop effective anticancer therapies, calling into question the use of rational drug...
9.
Astuti P, Pike T, Widberg C, Payne E, Harding A, Hancock J, et al.
J Biol Chem
. 2009 Oct;
284(49):33781-8.
PMID: 19801682
Activation of the mitogen-activated protein kinase (MAPK) pathway by growth factors or phorbol esters during G(2) phase delays entry into mitosis; however, the role of the MAPK pathway during G(2)/M...
10.
Lin J, Harding A, Giurisato E, Shaw A
Mol Cell Biol
. 2009 Feb;
29(8):2082-91.
PMID: 19188442
Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved signaling pathways that regulate cell fate decisions. They generate a wide range of signal outputs, including graded and digital responses. In T...