Andrey V Bzikadze
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Explore the profile of Andrey V Bzikadze including associated specialties, affiliations and a list of published articles.
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14
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1764
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Recent Articles
1.
Rhie A, Nurk S, Cechova M, Hoyt S, Taylor D, Altemose N, et al.
Nature
. 2023 Aug;
621(7978):344-354.
PMID: 37612512
The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure that includes long palindromes, tandem repeats and segmental duplications. As a result,...
2.
Bzikadze A, Pevzner P
Nat Methods
. 2023 Aug;
20(9):1346-1354.
PMID: 37580559
Even though the recent advances in 'complete genomics' revealed the previously inaccessible genomic regions, analysis of variations in centromeres and other extra-long tandem repeats (ETRs) faces an algorithmic challenge since...
3.
Zhang C, Bzikadze A, Safonova Y, Mirarab S
Front Immunol
. 2023 Jan;
13:1014439.
PMID: 36618367
Affinity maturation (AM) of B cells through somatic hypermutations (SHMs) enables the immune system to evolve to recognize diverse pathogens. The accumulation of SHMs leads to the formation of clonal...
4.
Bzikadze A, Mikheenko A, Pevzner P
Genome Res
. 2022 Nov;
32(11-12):2107-2118.
PMID: 36379716
Recent advancements in long-read sequencing have enabled the telomere-to-telomere (complete) assembly of a human genome and are now contributing to the haplotype-resolved complete assemblies of multiple human genomes. Because the...
5.
Kunyavskaya O, Dvorkina T, Bzikadze A, Alexandrov I, Pevzner P
Genome Res
. 2022 May;
32(6):1137-1151.
PMID: 35545449
Recent advances in long-read sequencing opened a possibility to address the long-standing questions about the architecture and evolution of human centromeres. They also emphasized the need for centromere annotation (partitioning...
6.
Mc Cartney A, Shafin K, Alonge M, Bzikadze A, Formenti G, Fungtammasan A, et al.
Nat Methods
. 2022 Apr;
19(6):687-695.
PMID: 35361931
Advances in long-read sequencing technologies and genome assembly methods have enabled the recent completion of the first telomere-to-telomere human genome assembly, which resolves complex segmental duplications and large tandem repeats,...
7.
Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze A, Mikheenko A, et al.
Science
. 2022 Mar;
376(6588):44-53.
PMID: 35357919
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the...
8.
Altemose N, Logsdon G, Bzikadze A, Sidhwani P, Langley S, Caldas G, et al.
Science
. 2022 Mar;
376(6588):eabl4178.
PMID: 35357911
Existing human genome assemblies have almost entirely excluded repetitive sequences within and near centromeres, limiting our understanding of their organization, evolution, and functions, which include facilitating proper chromosome segregation. Now,...
9.
Bankevich A, Bzikadze A, Kolmogorov M, Antipov D, Pevzner P
Nat Biotechnol
. 2022 Mar;
40(7):1075-1081.
PMID: 35228706
Although most existing genome assemblers are based on de Bruijn graphs, the construction of these graphs for large genomes and large k-mer sizes has remained elusive. This algorithmic challenge has...
10.
Dvorkina T, Kunyavskaya O, Bzikadze A, Alexandrov I, Pevzner P
Bioinformatics
. 2021 Jul;
37(Suppl_1):i196-i204.
PMID: 34252949
Motivation: Recent advances in long-read sequencing technologies led to rapid progress in centromere assembly in the last year and, for the first time, opened a possibility to address the long-standing...