Andrew Z Fire
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Explore the profile of Andrew Z Fire including associated specialties, affiliations and a list of published articles.
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83
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5439
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Recent Articles
1.
Ichikawa K, Shoura M, Artiles K, Jeong D, Owa C, Kobayashi H, et al.
bioRxiv
. 2024 Dec;
PMID: 39677790
The original 100.3 Mb reference genome for , generated from the wild-type laboratory strain N2, has been crucial for analysis of since 1998 and has been considered complete since 2005....
2.
Zheludev I, Edgar R, Lopez-Galiano M, de la Pena M, Babaian A, Bhatt A, et al.
Cell
. 2024 Oct;
187(23):6521-6536.e18.
PMID: 39481381
Here, we describe "obelisks," a class of heritable RNA elements sharing several properties: (1) apparently circular RNA ∼1 kb genome assemblies, (2) predicted rod-like genome-wide secondary structures, and (3) open...
3.
A genetic and microscopy toolkit for manipulating and monitoring regeneration in Macrostomum lignano
Hall R, Li H, Chai C, Vermeulen S, Bigasin R, Song E, et al.
Cell Rep
. 2024 Oct;
43(11):114892.
PMID: 39427313
Live imaging of regenerative processes can reveal how animals restore their bodies after injury through a cascade of dynamic cellular events. Here, we present a comprehensive toolkit for live imaging...
4.
Ortega J, Wahba L, Seemann J, Chen S, Fire A, Arur S
Sci Adv
. 2024 Oct;
10(40):eadp0466.
PMID: 39356768
Pachytene piRNAs, a Piwi-interacting RNA subclass in mammals, are hypothesized to regulate non-transposon sequences during spermatogenesis. piRNAs, the 21URNAs, are implicated in regulating coding sequences; the messenger RNA targets and...
5.
McCoy M, Fire A
Curr Biol
. 2024 Mar;
34(8):1635-1645.e3.
PMID: 38460513
How nervous systems evolved is a central question in biology. A diversity of synaptic proteins is thought to play a central role in the formation of specific synapses leading to...
6.
Zheludev I, Edgar R, Lopez-Galiano M, de la Pena M, Babaian A, Bhatt A, et al.
bioRxiv
. 2024 Jan;
PMID: 38293115
Here, we describe the "Obelisks," a previously unrecognised class of viroid-like elements that we first identified in human gut metatranscriptomic data. "Obelisks" share several properties: (i) apparently circular RNA ~1kb...
7.
Jeong D, Sundrani S, Hall R, Krupovic M, Koonin E, Fire A
Mol Biol Evol
. 2023 Dec;
40(12).
PMID: 38069639
Polintons are double-stranded DNA, virus-like self-synthesizing transposons widely found in eukaryotic genomes. Recent metagenomic discoveries of Polinton-like viruses are consistent with the hypothesis that Polintons invade eukaryotic host genomes through...
8.
Jeong D, Sundrani S, Hall R, Krupovic M, Koonin E, Fire A
bioRxiv
. 2023 Sep;
PMID: 37662302
Polintons are dsDNA, virus-like self-synthesizing transposons widely found in eukaryotic genomes. Recent metagenomic discoveries of Polinton-like viruses are consistent with the hypothesis that Polintons invade eukaryotic host genomes through infectious...
9.
Wang W, Artiles K, Machida S, Benkirane M, Jain N, Fire A
bioRxiv
. 2023 Jul;
PMID: 37398293
Replication of genetic material involves the creation of characteristic termini. Determining these termini is important to refine our understanding of the mechanisms involved in maintaining the genomes of cellular organisms...
10.
McCoy M, Fire A
bioRxiv
. 2023 Apr;
PMID: 37034725
How nervous systems evolved is a central question in biology. An increasing diversity of synaptic proteins is thought to play a central role in the formation of specific synapses leading...