Andrew W Hardy
Overview
Explore the profile of Andrew W Hardy including associated specialties, affiliations and a list of published articles.
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15
Citations
964
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Recent Articles
1.
Poirier M, Olivero O, Hardy A, Franchini G, Borojerdi J, Walker V, et al.
AIDS Res Ther
. 2009 Nov;
6:24.
PMID: 19895691
Background: WR1065 is the free-thiol metabolite of the cytoprotective aminothiol amifostine, which is used clinically at very high doses to protect patients against toxicity induced by radiation and chemotherapy. In...
2.
Walker D, Kajon A, Torres S, Carter M, McCash C, Swenberg J, et al.
Environ Mol Mutagen
. 2009 Apr;
50(6):460-72.
PMID: 19334055
The success of nucleoside reverse transcriptase inhibitors (NRTIs) in treating HIV-1 infection and reducing mother-to-child transmission of the virus during pregnancy is accompanied by evidence that NRTIs cause long-term health...
3.
Boasso A, Vaccari M, Fuchs D, Hardy A, Tsai W, Tryniszewska E, et al.
J Immunol
. 2009 Mar;
182(7):4313-20.
PMID: 19299731
Increased activity of IDO, which catalyzes the degradation of Trp into kynurenine (Kyn), is observed during HIV/SIV infection, and it may contribute to the persistence of HIV/SIV by suppressing antiviral...
4.
Herbeuval J, Nilsson J, Boasso A, Hardy A, Vaccari M, Cecchinato V, et al.
AIDS
. 2008 Dec;
23(1):35-40.
PMID: 19050384
Objective: To determine how antiretroviral therapy (ART) or HAART affects the expression of apoptotic ligands and their death receptors in the blood and lymphoid tissues of HIV-infected patients and simian...
5.
Boasso A, Hardy A, Anderson S, Dolan M, Shearer G
PLoS One
. 2008 Aug;
3(8):e2961.
PMID: 18698365
Infection by the human immunodeficiency virus (HIV) is characterized by functional impairment and chronic activation of T lymphocytes, the causes of which are largely unexplained. We cultured peripheral blood mononuclear...
6.
Boasso A, Hardy A, Landay A, Martinson J, Anderson S, Dolan M, et al.
Clin Immunol
. 2008 Jul;
129(1):132-44.
PMID: 18650129
The programmed death (PD)-1 interacts with its ligand (PDL-1) delivering a negative signal to T cells. During human immunodeficiency virus (HIV)-1 infection PD-1 and PDL-1 expressions are increased. Here we...
7.
Hardy A, Graham D, Shearer G, Herbeuval J
Proc Natl Acad Sci U S A
. 2007 Oct;
104(44):17453-8.
PMID: 17956986
Plasmacytoid dendritic cells (pDC) are key players in viral immunity and produce IFN-alpha after HIV-1 exposure, which in turn regulates TNF-related apoptosis-inducing ligand (TRAIL) expression by CD4(+) T cells. We...
8.
Boasso A, Herbeuval J, Hardy A, Anderson S, Dolan M, Fuchs D, et al.
Blood
. 2006 Dec;
109(8):3351-9.
PMID: 17158233
Infection with the human immunodeficiency virus type-1 (HIV) results in acute and progressive numeric loss of CD4(+) T-helper cells and functional impairment of T-cell responses. The mechanistic basis of the...
9.
Bedoya V, Boasso A, Hardy A, Rybak S, Shearer G, Rugeles M
AIDS Res Hum Retroviruses
. 2006 Sep;
22(9):897-907.
PMID: 16989616
Ribonucleases (RNases) have therapeutic potential against cancer and viral diseases and have been reported to inhibit replication of the human immunodeficiency virus type 1 (HIV-1) in chronically infected cell lines....
10.
Herbeuval J, Nilsson J, Boasso A, Hardy A, Kruhlak M, Anderson S, et al.
Proc Natl Acad Sci U S A
. 2006 Apr;
103(18):7000-5.
PMID: 16632604
Loss of CD4+ T cells, the hallmark of HIV pathogenesis, was suggested to be partly due to apoptosis. We recently reported that IFN-alpha produced by HIV-1-activated plasmacytoid dendritic cells (pDCs)...