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Andrew Silver

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Articles 96
Citations 1829
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Recent Articles
1.
Humphreys D, Lewis A, Pan-Castillo B, Berti G, Mein C, Wozniak E, et al.
J Cell Mol Med . 2024 Apr; 28(9):e18344. PMID: 38685679
Single cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach,...
2.
Lewis A, Humphreys D, Pan-Castillo B, Berti G, Felice C, Gordon H, et al.
J Crohns Colitis . 2023 Dec; 18(6):895-907. PMID: 38069679
Background And Aims: No effective therapeutic intervention exists for intestinal fibrosis in Crohn's disease [CD]. We characterized fibroblast subtypes, epigenetic and metabolic changes, and signalling pathways in CD fibrosis to...
3.
Gordon H, Wichmann K, Lewis A, Sanders T, Wildemann M, Hoti I, et al.
J Immunol . 2023 Nov; 212(1):96-106. PMID: 37955427
Retinoic acid, produced by intestinal dendritic cells (DCs), promotes T cell trafficking to the intestinal mucosa by upregulating α4β7 integrin and inhibiting the generation of cutaneous leukocyte Ag (CLA) required...
4.
Feakins R, Loughrey M, Silver A
J Pathol . 2023 Aug; 261(2):121-124. PMID: 37565277
Tumour budding (TB) describes single or small groups of neoplastic cells that lack continuity with an advancing tumour front. Poorly differentiated clusters (PDCs) are larger and qualitatively different. TB grade...
5.
Lewis A, Sanchez S, Berti G, Pan-Castillo B, Nijhuis A, Mehta S, et al.
Clin Sci (Lond) . 2022 Sep; 136(19):1405-1423. PMID: 36156078
Intestinal fibrosis and stricture formation is an aggressive complication of Crohns disease (CD), linked to increased morbidity and costs. The present study investigates the contribution of Wingless-Int-1 (Wnt) signalling to...
6.
Shailes H, Tse W, Freitas M, Silver A, Martin S
Front Oncol . 2022 Jun; 12:880552. PMID: 35712511
Background: Mutations in the tumor suppressor gene Adenomatous Polyposis Coli () are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of...
7.
Silver A
BMJ . 2022 Apr; 377:o994. PMID: 35444017
No abstract available.
8.
Silver A
BMJ . 2022 Apr; 377:o954. PMID: 35422433
No abstract available.
9.
Silver A
Nature . 2022 Mar; PMID: 35246644
No abstract available.
10.
Silver A
BMJ . 2022 Feb; 376:o420. PMID: 35177535
No abstract available.