Andrew P Levy
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Explore the profile of Andrew P Levy including associated specialties, affiliations and a list of published articles.
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129
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2528
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Recent Articles
1.
Shokhen M, Albeck A, Borisov V, Israel Y, Levy N, Levy A
Curr Res Struct Biol
. 2024 Oct;
8:100158.
PMID: 39431217
Mutations in the IQSEC2 gene result in severe intellectual disability, epilepsy and autism. The primary function of IQSEC2 is to serve as a guanine exchange factor (GEF) controlling the activation...
2.
Cahill L, Warren R, Bahn G, Carew A, Levy A, Sapp J, et al.
Am J Prev Cardiol
. 2024 May;
18:100681.
PMID: 38800835
Background: Intensive glycemic control reduced the risk of coronary artery disease (CAD) events among White ACCORD study participants with the haptoglobin (Hp)2-2 phenotype, and not among participants without the Hp2-2...
3.
Cahill L, Warren R, Carew A, Levy A, Sapp J, Samuel M, et al.
Diabetes Care
. 2024 Mar;
47(5):835-843.
PMID: 38484336
Objective: Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study participants with the haptoglobin (Hp)2-2 phenotype but not in...
4.
Warren R, Bancks M, Carew A, Levy A, Sapp J, Bahnson J, et al.
Cardiovasc Diabetol
. 2024 Feb;
23(1):82.
PMID: 38402400
Background: Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD) participants with the haptoglobin (Hp) 2-2 phenotype only. It...
5.
Warren R, Carew A, Andreou P, Levy A, Sapp J, Lache O, et al.
J Am Heart Assoc
. 2023 Sep;
12(19):e030288.
PMID: 37776200
Background The Hp (haptoglobin)2-2 phenotype (~40% of people) is associated with dysfunctional high-density lipoprotein (HDL) that is heavily oxidized in hyperglycemia, which may explain why raising HDL-cholesterol (HDL-C) does not...
6.
Cahill L, Warren R, Carew A, Levy A, Ginsberg H, Sapp J, et al.
Diabetes Care
. 2023 Aug;
46(11):1941-1948.
PMID: 37639669
Objective: Intensive glycemic therapy reduced coronary artery disease (CAD) events among White participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study with the haptoglobin (Hp)2-2 phenotype, while...
7.
Shokhen M, Walikonis R, Uversky V, Allbeck A, Zezelic C, Feldman D, et al.
J Biomol Struct Dyn
. 2023 Apr;
42(3):1268-1279.
PMID: 37078745
IQSEC2 gene mutations are associated with epilepsy, autism, and intellectual disability. The primary function IQSEC2, mediated via its Sec 7 domain, is to act as a guanine nucleotide exchange factor...
8.
Levy N, Borisov V, Lache O, Levy A
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902414
Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome sequencing of IQSEC2 patient DNA has led to the identification of numerous missense mutations that delineate...
9.
Jada R, Borisov V, Laury E, Halpert S, Levy N, Wagner S, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835332
Purposeful induction of fever for healing, including the treatment of epilepsy, was used over 2000 years ago by Hippocrates. More recently, fever has been demonstrated to rescue behavioral abnormalities in...
10.
Kane O, McCoy A, Jada R, Borisov V, Zag L, Zag A, et al.
Epilepsy Res
. 2022 Mar;
182:106907.
PMID: 35344748
IQSEC2 is an X-linked gene localized to the post synaptic density encoding a GTP exchange factor that regulates NMDA mediated changes in synaptic function. Mutations in the IQSEC2 gene are...