Andrew P Hutchins
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Explore the profile of Andrew P Hutchins including associated specialties, affiliations and a list of published articles.
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Articles
58
Citations
1694
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Recent Articles
1.
Zhang R, Li G, Zhang Q, Wang Z, Xiang D, Zhang X, et al.
Nucleic Acids Res
. 2025 Jan;
53(3).
PMID: 39876710
Cell fate determination at the chromatin level is not fully comprehended. Here, we report that c-JUN acts on chromatin loci to limit mesoderm cell fate specification as cells exit pluripotency....
2.
Ma G, Fu X, Zhou L, Babarinde I, Shi L, Yang W, et al.
Nat Cell Biol
. 2025 Jan;
27(2):232-245.
PMID: 39789220
The nuclear matrix, a proteinaceous gel composed of proteins and RNA, is an important nuclear structure that supports chromatin architecture, but its role in human pluripotent stem cells (hPSCs) has...
3.
Liang Y, Huang Z, Fan S, Li C, Huang L, Huang C, et al.
Microbiol Spectr
. 2024 Oct;
:e0152124.
PMID: 39475249
Importance: This study enhances our knowledge of the vaginal microbiota dynamics and the role of associated metabolites in individuals with vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis through shotgun sequencing...
4.
Zhang R, Wu M, Xiang D, Zhu J, Zhang Q, Zhong H, et al.
Cell Stem Cell
. 2024 Aug;
31(9):1298-1314.e8.
PMID: 39146934
Endogenous retroviruses (ERVs) occupy a significant part of the human genome, with some encoding proteins that influence the immune system or regulate cell-cell fusion in early extra-embryonic development. However, whether...
5.
Xu J, Guo P, Hao S, Shangguan S, Shi Q, Volpe G, et al.
Nat Genet
. 2024 Apr;
56(5):953-969.
PMID: 38627598
The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge...
6.
Ma R, Zhou X, Zhai X, Wang C, Hu R, Chen Y, et al.
Cell Prolif
. 2024 Feb;
57(5):e13591.
PMID: 38319150
Highly aggressive gastric cancer (HAGC) is a gastric cancer characterized by bone marrow metastasis and disseminated intravascular coagulation (DIC). Information about the disease is limited. Here we employed single-cell RNA...
7.
Yang Y, Jia W, Luo Z, Li Y, Liu H, Fu L, et al.
Nat Commun
. 2024 Jan;
15(1):583.
PMID: 38233381
In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta specification are understudied due to ethical barriers and the scarcity of embryos. Recent reports have shown that human...
8.
Li H, Chang L, Wu J, Huang J, Guan W, Bates L, et al.
Dev Cell
. 2023 Oct;
58(22):2510-2527.e7.
PMID: 37875119
Generating cells with the molecular and functional properties of embryo cells and with full developmental potential is an aim with fundamental biological significance. Here we report the in vitro generation...
9.
Li D, Luo L, Guo L, Wu C, Zhang R, Peng Y, et al.
Cell Biosci
. 2023 Oct;
13(1):191.
PMID: 37838693
Background: c-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological conditions, particularly in somatic cells. However, its role in early embryonic...
10.
Huang Y, Li L, An G, Yang X, Cui M, Song X, et al.
Nat Cell Biol
. 2023 Sep;
25(10):1520-1534.
PMID: 37723297
Human spermatogenesis is a highly ordered process; however, the roles of DNA methylation and chromatin accessibility in this process remain largely unknown. Here by simultaneously investigating the chromatin accessibility, DNA...