Andrew M Nelson
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Explore the profile of Andrew M Nelson including associated specialties, affiliations and a list of published articles.
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7
Citations
21
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Recent Articles
1.
Sharma P, Jiang Q, Li S, Ocke E, Tsotetsi K, Sukheja P, et al.
J Med Chem
. 2025 Mar;
68(5):5774-5803.
PMID: 40035499
A dire need exists for novel drugs to treat infection. In an effort to build on our early efforts targeting the MenG enzyme within the menaquinone biosynthetic pathway, we have...
2.
Warapande V, Meng F, Bozan A, Graff D, Fromer J, Mughal K, et al.
bioRxiv
. 2025 Feb;
PMID: 39974961
Drug discovery is inherently challenged by a multiple criteria decision making problem. The arduous path from hit discovery through lead optimization and preclinical candidate selection necessitates the evolution of a...
3.
Meyer C, Garzia A, Miller M, Huggins D, Myers R, Hoffmann H, et al.
Nature
. 2024 Dec;
637(8048):1178-1185.
PMID: 39663451
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The rapid development of highly effective vaccines against SARS-CoV-2 has altered the trajectory of the pandemic,...
4.
Alvarez N, Adam G, Howe J, Sharma V, Zimmerman M, Dolgov E, et al.
Viruses
. 2024 Jul;
16(7).
PMID: 39066320
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to be a global threat due to its ability to evolve and generate new subvariants, leading to new waves of infection....
5.
Vermillion M, Saari N, Bray M, Nelson A, Bullard R, Rudolph K, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612759
As a regulator of alveolo-capillary barrier integrity, Transient Receptor Potential Vanilloid 4 (TRPV4) antagonism represents a promising strategy for reducing pulmonary edema secondary to chemical inhalation. In an experimental model...
6.
Collins S, Chan-Li Y, Shenderov K, Gillich A, Nelson A, Loube J, et al.
bioRxiv
. 2024 Apr;
PMID: 38559095
Pulmonary fibrosis is a devastating disease with no effective treatments to cure, stop or reverse the unremitting, fatal fibrosis. A critical barrier to treating this disease is the lack of...
7.
Adney D, Lovaglio J, Schulz J, Yinda C, Avanzato V, Haddock E, et al.
JCI Insight
. 2022 Dec;
7(22).
PMID: 36509288
An animal model that fully recapitulates severe COVID-19 presentation in humans has been a top priority since the discovery of SARS-CoV-2 in 2019. Although multiple animal models are available for...
8.
Nolan K, Baer L, Karekar P, Nelson A, Stanford K, Doolittle L, et al.
Virology
. 2021 Apr;
559:111-119.
PMID: 33865074
Influenza A virus (IAV) infection alters lung epithelial cell metabolism in vitro by promoting a glycolytic shift. We hypothesized that this shift benefits the virus rather than the host and...
9.
Nelson A, Nolan K, Davis I
J Vis Exp
. 2020 Apr;
(157).
PMID: 32281980
The literature describes several methods for mouse intubation that either require visualization of the glottis through the oral cavity or incision in the ventral neck for direct confirmation of cannula...