Andrew Lofts
Overview
Explore the profile of Andrew Lofts including associated specialties, affiliations and a list of published articles.
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9
Citations
54
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Recent Articles
1.
Ali M, Wollenhaupt-Aguiar B, Wang Y, Abu-Hijleh F, Rigg N, de Azevedo Cardoso T, et al.
Int J Neuropsychopharmacol
. 2025 Jan;
28(2).
PMID: 39803900
Background: Bipolar disorder (BD) has been associated with impaired cellular resilience. Recent studies have shown abnormalities in the unfolded protein response (UPR) in BD. The UPR is the cellular response...
2.
Lofts A, Abu-Hijleh F, Rigg N, Winterhelt E, Kostashuk M, Monterio A, et al.
J Control Release
. 2024 Dec;
378:831-846.
PMID: 39730068
While bipolar disorder patients can benefit from lithium therapy, high levels of lithium in the serum can induce undesirable systemic side effects. Intranasal (IN) lithium delivery offers a potential solution...
3.
Lofts A, Campea M, Winterhelt E, Rigg N, Rivera N, Macdonald C, et al.
Int J Biol Macromol
. 2024 Aug;
277(Pt 4):134385.
PMID: 39111489
Intranasal (IN) delivery offers potential to deliver antipsychotic drugs with improved efficacy to the brain. However, the solubilization of such drugs and the frequency of required re-application both represent challenges...
4.
Singh A, Lofts A, Krishnan R, Campea M, Chen L, Wan Y, et al.
Nanoscale Adv
. 2024 May;
6(9):2487-2498.
PMID: 38694467
Comb copolymer analogues of poly(lactic acid)-polyethylene glycol block copolymers (PLA--PEG) offer potential to overcome the inherent chemistry and stability limitations of their linear block copolymer counterparts. Herein, we examine the...
5.
Pan Z, Dorogin J, Lofts A, Randhawa G, Xu F, Slick R, et al.
Adv Healthc Mater
. 2024 Apr;
13(19):e2304397.
PMID: 38684223
A zwitterionic injectable and degradable hydrogel based on hydrazide and aldehyde-functionalized [2-(methacryloyloxy)ethyl] dimethyl-(3-sulfopropyl)ammonium hydroxide (DMAPS) precursor polymers that can address practical in vivo needs is reported. Zwitterion fusion interactions between...
6.
Toufanian S, Mohammed J, Winterhelt E, Lofts A, Dave R, Coombes B, et al.
ACS Appl Bio Mater
. 2024 Feb;
7(3):1947-1957.
PMID: 38394042
Methicillin-resistant (MRSA) is associated with high levels of morbidity and is considered a difficult-to-treat infection, often requiring nonstandard treatment regimens and antibiotics. Since over 40% of the emerging antibiotic compounds...
7.
Campea M, Lofts A, Xu F, Yeganeh M, Kostashuk M, Hoare T
ACS Appl Mater Interfaces
. 2023 May;
15(21):25324-25338.
PMID: 37192117
Although nanoparticle-based chemotherapeutic strategies have gained in popularity, the efficacy of such therapies is still limited in part due to the different nanoparticle sizes needed to best accommodate different parts...
8.
Lofts A, Abu-Hijleh F, Rigg N, Mishra R, Hoare T
CNS Drugs
. 2022 Jun;
36(7):739-770.
PMID: 35759210
While the intranasal administration of drugs to the brain has been gaining both research attention and regulatory success over the past several years, key fundamental and translational challenges remain to...
9.
Li X, Montague E, Pollinzi A, Lofts A, Hoare T
Small
. 2021 Dec;
18(6):e2104632.
PMID: 34936204
Multiple biological barriers must be considered in the design of nanomedicines, including prolonged blood circulation, efficient accumulation at the target site, effective penetration into the target tissue, selective uptake of...
10.
Majcher M, Babar A, Lofts A, Leung A, Li X, Abu-Hijleh F, et al.
J Control Release
. 2020 Dec;
330:738-752.
PMID: 33383097
Existing oral or injectable antipsychotic drug delivery strategies typically demonstrate low bioavailability to targeted brain regions, incentivizing the development of alternative delivery strategies. Delivery via the nasal cavity circumvents multiple...