Andrew J Cant
Overview
Explore the profile of Andrew J Cant including associated specialties, affiliations and a list of published articles.
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Articles
89
Citations
3138
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Recent Articles
1.
Griffin H, Ceron-Gutierrez L, Gharahdaghi N, Ebrahimi S, Davies S, Loo P, et al.
N Engl J Med
. 2024 Jul;
391(5):434-441.
PMID: 39083772
We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling. After B-cell-depletion therapy and an associated...
2.
Cant A, Chandra A, Munro E, Rao V, Lucas C
J Allergy Clin Immunol Pract
. 2023 Sep;
12(1):69-78.
PMID: 37777067
The phosphoinositide 3-kinase (PI3K) pathway regulates diverse cellular processes, with finely tuned PI3Kδ activity being crucial for immune cell development and function. Genetic hyperactivation of PI3Kδ causes the inborn error...
3.
Tsilifis C, Lum S, Nademi Z, Hambleton S, Flood T, Williams E, et al.
J Clin Immunol
. 2022 Mar;
42(4):851-858.
PMID: 35305204
Hematopoietic stem cell transplantation and gene therapy are the only curative therapies for severe combined immunodeficiency (SCID). In patients lacking a matched donor, TCRαβ/CD19-depleted haploidentical family donor transplant (TCRαβ-HaploSCT) is...
4.
Shiraki M, Williams E, Yokoyama N, Shinoda K, Nademi Z, Matsumoto K, et al.
J Clin Immunol
. 2021 Aug;
41(8):1954-1956.
PMID: 34427832
No abstract available.
5.
Ouahed J, Kelsen J, Spessott W, Kooshesh K, Sanmillan M, Dawany N, et al.
J Crohns Colitis
. 2021 Apr;
15(11):1908-1919.
PMID: 33891011
Background And Aims: Very early onset inflammatory bowel disease [VEOIBD] is characterized by intestinal inflammation affecting infants and children less than 6 years of age. To date, over 60 monogenic...
6.
Harrison S, Tsilifis C, Slatter M, Nademi Z, Worth A, Veys P, et al.
J Clin Immunol
. 2021 Feb;
41(5):934-943.
PMID: 33523338
Autosomal dominant hyper-IgE syndrome caused by dominant-negative loss-of-function mutations in signal transducer and activator of transcription factor 3 (STAT3) (STAT3-HIES) is a rare primary immunodeficiency with multisystem pathology. The quality...
7.
Spegarova J, Lawless D, Mohamad S, Engelhardt K, Doody G, Shrimpton J, et al.
Blood
. 2020 Jun;
136(9):1055-1066.
PMID: 32518946
Molecular dissection of inborn errors of immunity can help to elucidate the nonredundant functions of individual genes. We studied 3 children with an immune dysregulation syndrome of susceptibility to infection,...
8.
Elfeky R, Lucchini G, Lum S, Ottaviano G, Builes N, Nademi Z, et al.
Blood Adv
. 2020 Jun;
4(11):2418-2429.
PMID: 32492158
This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 children underwent...
9.
Chiesa R, Standing J, Winter R, Nademi Z, Chu J, Pinner D, et al.
Clin Pharmacol Ther
. 2019 Nov;
108(2):264-273.
PMID: 31701524
Treosulfan is given off-label in pediatric allogeneic hematopoietic stem cell transplant. This study investigated treosulfan's pharmacokinetics (PKs), efficacy, and safety in a prospective trial. Pediatric patients (n = 87) receiving...
10.
Al Shehri T, Gilmour K, Gothe F, Loughlin S, Bibi S, Rowan A, et al.
J Clin Immunol
. 2019 Sep;
39(8):776-785.
PMID: 31512162
Mutations in the coiled-coil and DNA-binding domains of STAT1 lead to delayed STAT1 dephosphorylation and subsequently gain-of-function. The associated clinical phenotype is broad and can include chronic mucocutaneous candidiasis (CMC)...