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Andrew Gifford

Explore the profile of Andrew Gifford including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 427
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Recent Articles
1.
Cheung B, Mittra R, Murray J, Wang Q, Seneviratne J, Raipuria M, et al.
Commun Biol . 2024 Oct; 7(1):1322. PMID: 39402275
MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to generate founders...
2.
Seneviratne J, Carter D, Mittra R, Gifford A, Kim P, Luo J, et al.
Int J Cancer . 2022 Nov; 152(7):1399-1413. PMID: 36346110
The mitochondrion is a gatekeeper of apoptotic processes, and mediates drug resistance to several chemotherapy agents used to treat cancer. Neuroblastoma is a common solid cancer in young children with...
3.
Lau L, Mayoh C, Xie J, Barahona P, Mackenzie K, Wong M, et al.
EMBO Mol Med . 2021 Dec; 14(4):e14608. PMID: 34927798
Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. We developed a precision medicine platform of rapid high-throughput drug...
4.
Tsoli M, Wadham C, Pinese M, Failes T, Joshi S, Mould E, et al.
Cancer Biol Ther . 2018 Oct; 19(12):1078-1087. PMID: 30299205
Pediatric high grade gliomas (HGG) are primary brain malignancies that result in significant morbidity and mortality. One of the challenges in their treatment is inter- and intra-tumoral heterogeneity. Precision medicine...
5.
Ziegler D, Wong M, Mayoh C, Kumar A, Tsoli M, Mould E, et al.
Br J Cancer . 2018 Sep; 119(6):693-696. PMID: 30220707
Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40%...
6.
Cheng Q, Aravind A, Buckley M, Gifford A, Parvin B
Sci Rep . 2015 Sep; 5:13685. PMID: 26347365
To date, in situ visualization of microbial density has remained an open problem. Here, functionalized buckyballs (e.g., C60-pyrrolidine tris acid) are shown to be a versatile platform that allows internalization...
7.
Benveniste H, Ma Y, Dhawan J, Gifford A, Smith S, Feinstein I, et al.
Ann N Y Acad Sci . 2007 Apr; 1097:12-29. PMID: 17413006
The wide variety of transgenic mouse models of Alzheimer's disease (AD) reflects the search for specific genes that influence AD pathology and the drive to create a clinically relevant animal...
8.
Thanos P, Dimitrakakis E, Rice O, Gifford A, Volkow N
Behav Brain Res . 2005 Sep; 164(2):206-13. PMID: 16140402
Cannabinoids are postulated to play a role in modulating the reinforcing effects of abused drugs, including alcohol. Experiment 1 examined alcohol self-administration in cannabinoid CB1 receptor knockout (KO), heterozygous (HT)...
9.
Li Z, Gifford A, Liu Q, Thotapally R, Ding Y, Makriyannis A, et al.
Nucl Med Biol . 2005 May; 32(4):361-6. PMID: 15878505
Introduction: The mammalian brain contains abundant G protein-coupled cannabinoid CB(1) receptors that respond to Delta(9)-tetrahydrocannabinol, the active ingredient of cannabis. The availability of a positron emission tomography (PET) radioligand would...
10.
Li Z, Ding Y, Gifford A, Fowler J, Gatley J
Bioconjug Chem . 2003 Mar; 14(2):287-94. PMID: 12643738
The synthesis of a benzophenone-based labeling compound designed for comparative imaging studies with both in vivo positron emission tomograph (PET) and single-photon computed tomography (SPECT) and ex vivo autoradiography is...