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Andrew F Adler

Explore the profile of Andrew F Adler including associated specialties, affiliations and a list of published articles. Areas
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Articles 23
Citations 1473
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Recent Articles
11.
Adler A, Lee-Kubli C, Kumamaru H, Kadoya K, Tuszynski M
Stem Cell Reports . 2017 May; 8(6):1525-1533. PMID: 28479302
Neural progenitor cells grafted to sites of spinal cord injury have supported electrophysiological and functional recovery in several studies. Mechanisms associated with graft-related improvements in outcome appear dependent on functional...
12.
Christoforou N, Chakraborty S, Kirkton R, Adler A, Addis R, Leong K
Sci Rep . 2017 Jan; 7:40285. PMID: 28071742
Transdifferentiation has been described as a novel method for converting human fibroblasts into induced cardiomyocyte-like cells. Such an approach can produce differentiated cells to study physiology or pathophysiology, examine drug...
13.
Black J, Adler A, Wang H, DIppolito A, Hutchinson H, Reddy T, et al.
Cell Stem Cell . 2016 Aug; 19(3):406-14. PMID: 27524438
Overexpression of exogenous fate-specifying transcription factors can directly reprogram differentiated somatic cells to target cell types. Here, we show that similar reprogramming can also be achieved through the direct activation...
14.
Gallego-Perez D, Otero J, Czeisler C, Ma J, Ortiz C, Gygli P, et al.
Nanomedicine . 2015 Dec; 12(2):399-409. PMID: 26711960
From The Clinical Editor: In the field of regenerative medicine, the ability to direct cell fate by nuclear reprogramming is an important facet in terms of clinical application. In this...
15.
Kulangara K, Adler A, Wang H, Chellappan M, Hammett E, Yasuda R, et al.
Biomaterials . 2014 Apr; 35(20):5327-5336. PMID: 24709523
Cellular reprogramming holds tremendous potential for cell therapy and regenerative medicine. Recently, fibroblasts have been directly converted into induced neurons (iNs) by overexpression of the neuronal transcription factors Ascl1, Brn2...
16.
Perez-Pinera P, Kocak D, Vockley C, Adler A, Kabadi A, Polstein L, et al.
Nat Methods . 2013 Jul; 10(10):973-6. PMID: 23892895
Technologies for engineering synthetic transcription factors have enabled many advances in medical and scientific research. In contrast to existing methods based on engineering of DNA-binding proteins, we created a Cas9-based...
17.
Christoforou N, Chellappan M, Adler A, Kirkton R, Wu T, Addis R, et al.
PLoS One . 2013 May; 8(5):e63577. PMID: 23704920
Transient overexpression of defined combinations of master regulator genes can effectively induce cellular reprogramming: the acquisition of an alternative predicted phenotype from a differentiated cell lineage. This can be of...
18.
Adler A, Grigsby C, Kulangara K, Wang H, Yasuda R, Leong K
Mol Ther Nucleic Acids . 2013 Jan; 1:e32. PMID: 23344148
Transdifferentiation, where differentiated cells are reprogrammed into another lineage without going through an intermediate proliferative stem cell-like stage, is the next frontier of regenerative medicine. Wernig et al. first described...
19.
Le D, Kulangara K, Adler A, Leong K, Ashby V
Adv Mater . 2011 Jun; 23(29):3278-83. PMID: 21626577
No abstract available.
20.
Adler A, Leong K
Nano Today . 2011 Mar; 5(6):553-569. PMID: 21383869
Significant effort continues to be exerted toward the improvement of transfection mediated by nonviral vectors. These endeavors are often focused on the design of particulate carriers with properties that encourage...