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Andrew C Palfreeman

Explore the profile of Andrew C Palfreeman including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 164
Followers 0
Related Specialties
Rheumatology
Allergy & Immunology
Pharmacology
Top 10 Co-Authors
Fionula M Brennan
Parisa Amjadi
Ching Li
Marc Feldmann
Alan Kennedy
Patricia Green
Fiona E McCann
Gideon Agbanoma
Melanie Andrews
Anna Andersson
Published In
Arthritis Res Ther
J Immunol
Immunology
Drug Des Devel Ther
Proc Natl Acad Sci U S A
Affiliations
Soon will be listed here.
Recent Articles
1.
New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast
Palfreeman A, McNamee K, McCann F
Drug Des Devel Ther . 2013 Apr; 7:201-10. PMID: 23569359
Psoriasis is a chronic inflammatory skin disease, most commonly resulting in the occurrence of red and silver scaly plaques. About 30% of psoriasis sufferers develop psoriatic arthritis (PsA), a disorder...
2.
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism
Agbanoma G, Li C, Ennis D, Palfreeman A, Williams L, Brennan F
J Immunol . 2012 Jan; 188(3):1307-17. PMID: 22219323
Previously, we demonstrated that spontaneous TNF-α production by macrophages in rheumatoid arthritis (RA) synovial tissue is largely driven by contact-dependent activation with T cells in that tissue. Whereas abundant IL-10...
3.
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells
Beavis P, Gregory B, Green P, Cribbs A, Kennedy A, Amjadi P, et al.
Proc Natl Acad Sci U S A . 2011 Sep; 108(40):16717-22. PMID: 21926327
Increasing evidence suggests that regulatory T cell (Treg) function is impaired in chronic inflammatory diseases such as rheumatoid arthritis (RA). Here we demonstrate that Tregs are unable to modulate the...
4.
Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor
Li C, Beavis P, Palfreeman A, Amjadi P, Kennedy A, Brennan F
Immunology . 2010 Sep; 132(1):104-10. PMID: 20875074
Peripheral blood CD4(+) CD45RO(+) T cells activated in vitro are able to induce expression of tumour necrosis factor-α (TNF-α) in monocytes via a contact-dependent mechanism. Activation is achieved either with...
5.
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
McCann F, Palfreeman A, Andrews M, Perocheau D, Inglis J, Schafer P, et al.
Arthritis Res Ther . 2010 Jun; 12(3):R107. PMID: 20525198
Introduction: Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis of the second messenger, cAMP. Inhibition of PDE4 has previously been shown to suppress immune...
6.
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
Brennan F, Smith N, Owen S, Li C, Amjadi P, Green P, et al.
Arthritis Res Ther . 2008 Mar; 10(2):R36. PMID: 18353171
Background: Previously we described a system whereby human peripheral blood T cells stimulated for 8 days in a cytokine cocktail acquired effector function for contact-dependent induction of proinflammatory cytokines from...