Andrew C Braisted
Overview
Explore the profile of Andrew C Braisted including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
6
Citations
486
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
He M, Stroustrup Smith A, Oslob J, Flanagan W, Braisted A, Whitty A, et al.
Science
. 2005 Nov;
310(5750):1022-5.
PMID: 16284179
We have identified a small-molecule inhibitor of tumor necrosis factor alpha (TNF-alpha) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-alpha activity in biochemical and...
2.
Raimundo B, Oslob J, Braisted A, Hyde J, McDowell R, Randal M, et al.
J Med Chem
. 2004 May;
47(12):3111-30.
PMID: 15163192
Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2...
3.
Erlanson D, Wells J, Braisted A
Annu Rev Biophys Biomol Struct
. 2004 May;
33:199-223.
PMID: 15139811
The genomics revolution has provided a deluge of new targets for drug discovery. To facilitate the drug discovery process, many researchers are turning to fragment-based approaches to find lead molecules...
4.
Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2
Hyde J, Braisted A, Randal M, Arkin M
Biochemistry
. 2003 May;
42(21):6475-83.
PMID: 12767230
The cytokine hormone interleukin-2 (IL-2) contains a highly adaptive region that binds small, druglike molecules. The binding properties of this adaptive region have been explored using a "tethering" method that...
5.
Braisted A, Oslob J, DeLano W, Hyde J, McDowell R, Waal N, et al.
J Am Chem Soc
. 2003 Mar;
125(13):3714-5.
PMID: 12656598
Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Ralpha) with cell-based activity. Starting with a low micromolar...
6.
Arkin M, Randal M, DeLano W, Hyde J, Luong T, Oslob J, et al.
Proc Natl Acad Sci U S A
. 2003 Feb;
100(4):1603-8.
PMID: 12582206
Understanding binding properties at protein-protein interfaces has been limited to structural and mutational analyses of natural binding partners or small peptides identified by phage display. Here, we present a high-resolution...