Andrew Allchorne
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Explore the profile of Andrew Allchorne including associated specialties, affiliations and a list of published articles.
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12
Citations
756
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Recent Articles
1.
Paiva L, Lozic M, Allchorne A, Grinevich V, Ludwig M
J Neuroendocrinol
. 2021 Apr;
33(5):e12970.
PMID: 33851744
Oxytocin is primarily synthesised in the brain and is widely known for its role in lactation and parturition after being released into the blood from the posterior pituitary gland. Nevertheless,...
2.
Effects of optogenetic stimulation of vasopressinergic retinal afferents on suprachiasmatic neurones
Hume C, Allchorne A, Grinevich V, Leng G, Ludwig M
J Neuroendocrinol
. 2019 Nov;
31(12):e12806.
PMID: 31677199
Physiological circadian rhythms are orchestrated by the hypothalamic suprachiasmatic nucleus (SCN). The activity of SCN cells is synchronised by environmental signals, including light information from retinal ganglion cells (RGCs). We...
3.
Vinuela-Fernandez I, Sun L, Jerina H, Curtis J, Allchorne A, Gooding H, et al.
Neuropharmacology
. 2013 Nov;
79:136-51.
PMID: 24269608
Effective relief from chronic hypersensitive pain states remains an unmet need. Here we report the discovery that the TRPM8 ion channel, co-operating with the 5-HT(1B) receptor (5-HT(1B)R) in a subset...
4.
Costigan M, Belfer I, Griffin R, Dai F, Barrett L, Coppola G, et al.
Brain
. 2010 Aug;
133(9):2519-27.
PMID: 20724292
Not all patients with nerve injury develop neuropathic pain. The extent of nerve damage and age at the time of injury are two of the few risk factors identified to...
5.
Jones E, Vinuela-Fernandez I, Eager R, Delaney A, Anderson H, Patel A, et al.
Pain
. 2007 Oct;
132(3):321-331.
PMID: 17935886
Laminitis is a common debilitating disease in horses that involves painful disruption of the lamellar dermo-epidermal junction within the hoof. This condition is often refractory to conventional anti-inflammatory analgesia and...
6.
Tegeder I, Costigan M, Griffin R, Abele A, Belfer I, Schmidt H, et al.
Nat Med
. 2006 Oct;
12(11):1269-77.
PMID: 17057711
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential cofactor for catecholamine,...
7.
McCampbell A, Truong D, Broom D, Allchorne A, Gable K, Cutler R, et al.
Hum Mol Genet
. 2005 Oct;
14(22):3507-21.
PMID: 16210380
Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details of the molecular pathophysiology remain obscure. SPTLC1 encodes one subunit of serine palmitoyltransferase...
8.
Wang H, Kohno T, Amaya F, Brenner G, Ito N, Allchorne A, et al.
J Neurosci
. 2005 Sep;
25(35):7986-92.
PMID: 16135755
Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold. We now show that the B2 kinin receptor is expressed in rat dorsal horn neurons and that bradykinin, a...
9.
Decosterd I, Allchorne A, Woolf C
Anesth Analg
. 2004 Jul;
99(2):457-63, table of contents.
PMID: 15271725
Progressive tactile hypersensitivity (PTH) manifesting after sciatic nerve crush and spared nerve injury (SNI) are two distinct rodent experimental models of neuropathic pain. PTH develops months after recovery from the...
10.
Costigan M, Samad T, Allchorne A, Lanoue C, Tate S, Woolf C
Mol Cell Neurosci
. 2003 Oct;
24(1):106-16.
PMID: 14550772
The regulators of G-protein signaling (RGS) proteins are a family of intracellular modulators of G-protein coupled receptor (GPCR) sensitivity. They act as GTPase accelerating proteins returning the Galpha subunit back...