Andrei V Bakin
Overview
Explore the profile of Andrei V Bakin including associated specialties, affiliations and a list of published articles.
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29
Citations
1309
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Recent Articles
1.
Alruwaili M, Zonneville J, Naranjo M, Serio H, Melendy T, Straubinger R, et al.
Cell Rep Med
. 2024 Feb;
5(3):101434.
PMID: 38387463
The tumor-suppressor p53 is commonly inactivated in colorectal cancer and pancreatic ductal adenocarcinoma, but existing treatment options for p53-mutant (p53) cancer are largely ineffective. Here, we report a therapeutic strategy...
2.
Xing Z, Li Y, Cortes-Gomez E, Jiang X, Gao S, Pao A, et al.
Hum Mol Genet
. 2023 Apr;
32(13):2205-2218.
PMID: 37014740
As an aneuploidy, trisomy is associated with mammalian embryonic and postnatal abnormalities. Understanding the underlying mechanisms involved in mutant phenotypes is broadly important and may lead to new strategies to...
3.
Martin J, Sims J, Gupta A, Bakin A, Ohm J
Cancer Res Commun
. 2022 Nov;
2(6):471-482.
PMID: 36338546
Ewing sarcoma is an aggressive childhood cancer for which treatment options remain limited and toxic. There is an urgent need for the identification of novel therapeutic strategies. Our group has...
4.
Zonneville J, Wang M, Alruwaili M, Smith B, Melnick M, Eng K, et al.
Commun Biol
. 2021 Jul;
4(1):862.
PMID: 34253820
Breast carcinomas commonly carry mutations in the tumor suppressor p53, although therapeutic efforts to target mutant p53 have previously been unfruitful. Here we report a selective combination therapy strategy for...
5.
Zonneville J, Colligan S, Grant S, Miller A, Wallace P, Abrams S, et al.
Int J Cancer
. 2020 May;
147(8):2279-2292.
PMID: 32452014
Patients with metastatic breast cancer (MBC) have limited therapeutic options and novel treatments are critically needed. Prior research implicates tumor-induced mobilization of myeloid cell populations in metastatic progression, as well...
6.
Zonneville J, Wong V, Limoge M, Nikiforov M, Bakin A
Sci Rep
. 2020 Feb;
10(1):2517.
PMID: 32054925
Triple-negative breast cancer (TNBC) is among the most aggressive forms of breast cancer with limited therapeutic options. TAK1 is implicated in aggressive behavior of TNBC, while means are not fully...
7.
Fink E, Moparthy S, Bagati A, Bianchi-Smiraglia A, Lipchick B, Wolff D, et al.
Cell Rep
. 2018 Oct;
25(1):212-223.e4.
PMID: 30282030
Transcription factor XBP1s, activated by endoplasmic reticulum (ER) stress in a dose-dependent manner, plays a central role in adaptive unfolded protein response (UPR) via direct activation of multiple genes controlling...
8.
Zonneville J, Safina A, Truskinovsky A, Arteaga C, Bakin A
BMC Cancer
. 2018 Jun;
18(1):670.
PMID: 29921235
Background: The breast cancer microenvironment promotes tumor vascularization through the complex interactions involving tumor-associated fibroblasts (TAFs). Emerging data indicate that TAFs increase production and signaling by TGF-β cytokines, while the...
9.
Liu C, Yu T, Xing Z, Jiang X, Li Y, Pao A, et al.
Oncotarget
. 2018 Feb;
9(4):4773-4786.
PMID: 29435140
Individuals with Down syndrome (DS) frequently have hematopoietic abnormalities, including transient myeloproliferative disorder and acute megakaryoblastic leukemia which are often accompanied by acquired GATA1 mutations that produce a truncated protein,...
10.
Limoge M, Safina A, Truskinovsky A, Aljahdali I, Zonneville J, Gruevski A, et al.
Oncotarget
. 2017 Oct;
8(37):61969-61981.
PMID: 28977919
The breast carcinoma microenvironment strikingly influences cancer progression and response to therapy. Various cell types in the carcinoma microenvironment show significant activity of p38 mitogen-activated protein kinase (MAPK), although the...