Andreas Schlattl
Overview
Explore the profile of Andreas Schlattl including associated specialties, affiliations and a list of published articles.
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14
Citations
2719
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Recent Articles
1.
Wilding B, Scharn D, Bose D, Baum A, Santoro V, Chetta P, et al.
Nat Cancer
. 2022 Jul;
3(7):821-836.
PMID: 35883003
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine kinase domain and cluster...
2.
Koferle A, Schlattl A, Hormann A, Thatikonda V, Popa A, Spreitzer F, et al.
Cell Rep
. 2022 Apr;
39(2):110636.
PMID: 35417719
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of functional redundancies can create de novo vulnerabilities that are specific to cancer cells. Here, we systematically search for...
3.
Ehrenhofer-Wolfer K, Puchner T, Schwarz C, Rippka J, Blaha-Ostermann S, Strobl U, et al.
Sci Rep
. 2019 Aug;
9(1):11661.
PMID: 31406271
SMARCA4/BRG1 and SMARCA2/BRM, the two mutually exclusive catalytic subunits of the BAF complex, display a well-established synthetic lethal relationship in SMARCA4-deficient cancers. Using CRISPR-Cas9 screening, we identify SMARCA4 as a...
4.
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
Lieb S, Blaha-Ostermann S, Kamper E, Rippka J, Schwarz C, Ehrenhofer-Wolfer K, et al.
Elife
. 2019 Mar;
8.
PMID: 30910006
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a...
5.
Leznicki P, Natarajan J, Bader G, Spevak W, Schlattl A, Abdul Rehman S, et al.
J Cell Sci
. 2018 Apr;
131(10).
PMID: 29685892
Protein ubiquitylation is a dynamic post-translational modification that can be reversed by deubiquitylating enzymes (DUBs). It is unclear how the small number (∼100) of DUBs present in mammalian cells regulate...
6.
van der Lelij P, Lieb S, Jude J, Wutz G, Santos C, Falkenberg K, et al.
Elife
. 2017 Jul;
6.
PMID: 28691904
Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin...
7.
Putz E, Majoros A, Gotthardt D, Prchal-Murphy M, Zebedin-Brandl E, Fux D, et al.
Oncoimmunology
. 2016 Oct;
5(9):e1186314.
PMID: 27757297
STAT1 is an important regulator of NK cell maturation and cytotoxicity. Although the consequences of -deficiency have been described in detail the underlying molecular functions of STAT1 in NK cells...
8.
Waizenegger I, Baum A, Steurer S, Stadtmuller H, Bader G, Schaaf O, et al.
Mol Cancer Ther
. 2016 Feb;
15(3):354-65.
PMID: 26916115
BI 882370 is a highly potent and selective RAF inhibitor that binds to the DFG-out (inactive) conformation of the BRAF kinase. The compound inhibited proliferation of human BRAF-mutant melanoma cells...
9.
Sudmant P, Rausch T, Gardner E, Handsaker R, Abyzov A, Huddleston J, et al.
Nature
. 2015 Oct;
526(7571):75-81.
PMID: 26432246
Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classes comprising...
10.
Hammer C, Degenhardt F, Priebe L, Stutz A, Heilmann S, Waszak S, et al.
Bipolar Disord
. 2014 Apr;
16(7):764-8.
PMID: 24754353
Objectives: Copy number variants (CNVs) have been shown to affect susceptibility for neuropsychiatric disorders. To date, studies implicating the serotonergic system in complex conditions have just focused on single nucleotide...