Andreas S Puschnik
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Explore the profile of Andreas S Puschnik including associated specialties, affiliations and a list of published articles.
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25
Citations
1532
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Recent Articles
1.
Puccinelli R, Sama S, Worthington C, Puschnik A, Pak J, Gomez-Sjoberg R
PLoS One
. 2024 Feb;
19(2):e0297879.
PMID: 38394072
Liquid chromatography purification of multiple recombinant proteins, in parallel, could catalyze research and discovery if the processes are fast and approach the robustness of traditional, "one-protein-at-a-time" purification. Here, we report...
2.
Sunshine S, Puschnik A, Replogle J, Laurie M, Liu J, Zha B, et al.
Nat Commun
. 2023 Oct;
14(1):6245.
PMID: 37803001
Genomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but efficient delineation of their molecular roles during infection remains a challenge. Here we use Perturb-seq, combining genetic perturbations...
3.
Zengel J, Wang Y, Seo J, Ning K, Hamilton J, Wu B, et al.
Nat Methods
. 2023 Jun;
20(7):1070-1081.
PMID: 37291262
The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. However, generating these models is time-...
4.
Ngo A, Puschnik A
J Virol
. 2023 Mar;
97(4):e0194822.
PMID: 36971544
Adeno-associated virus (AAV) vectors are one of the leading platforms for gene delivery for the treatment of human genetic diseases, but the antiviral cellular mechanisms that interfere with optimal transgene...
5.
Ng W, Kwek S, Sun B, Yousefi M, Ong E, Tan H, et al.
Open Biol
. 2022 Dec;
12(12):220227.
PMID: 36514984
The four dengue viruses (DENVs) have evolved multiple mechanisms to ensure its survival. Among these mechanisms is the ability to regulate its replication rate, which may contribute to avoiding premature...
6.
Vargas-Zapata V, Geiger K, Tran D, Ma J, Mao X, Puschnik A, et al.
bioRxiv
. 2022 Dec;
PMID: 36482965
Endoplasmic reticulum (ER) aminopeptidase associated with antigen processing (ERAAP) trims peptide precursors in the ER for presentation by major histocompatibility (MHC)-I molecules to surveying CD8 T-cells. This function allows ERAAP...
7.
Richards C, Jabs S, Qiao W, Varanese L, Schweizer M, Mosen P, et al.
Science
. 2022 Sep;
378(6615):eabn5648.
PMID: 36074821
Lysosomes are key degradative compartments of the cell. Transport to lysosomes relies on GlcNAc-1-phosphotransferase-mediated tagging of soluble enzymes with mannose 6-phosphate (M6P). GlcNAc-1-phosphotransferase deficiency leads to the severe lysosomal storage...
8.
Biering S, Sarnik S, Wang E, Zengel J, Leist S, Schafer A, et al.
Nat Genet
. 2022 Jul;
54(8):1078-1089.
PMID: 35879412
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors...
9.
Liu J, Knopp K, Rackaityte E, Wang C, Laurie M, Sunshine S, et al.
mBio
. 2022 May;
13(3):e0020522.
PMID: 35502904
Lymphocytic choriomeningitis virus (LCMV) is a well-studied mammarenavirus that can be fatal in congenital infections. However, our understanding of LCMV and its interactions with human host factors remains incomplete. Here,...
10.
Kulsuptrakul J, Wang R, Meyers N, Ott M, Puschnik A
Cell Rep
. 2021 Mar;
34(11):108859.
PMID: 33730579
Hepatitis A virus (HAV) is a positive-sense RNA virus causing acute inflammation of the liver. Here, using a genome-scale CRISPR screen, we provide a comprehensive picture of the cellular factors...