Andreas-David Brunner
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Explore the profile of Andreas-David Brunner including associated specialties, affiliations and a list of published articles.
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23
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2023
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Recent Articles
1.
Jones A, Bajrami B, Campbell M, Erzurumluoglu A, Guo Q, Chen H, et al.
Hepatol Commun
. 2024 Apr;
8(5).
PMID: 38619429
Background: Mutations in the gene MTARC1 (mitochondrial amidoxime-reducing component 1) protect carriers from metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. MTARC1 encodes the mARC1 enzyme, which is localized to the mitochondria...
2.
Neukam M, Sala P, Brunner A, Ganss K, Palladini A, Grzybek M, et al.
Cell Rep
. 2024 Feb;
43(3):113836.
PMID: 38421874
Endocrine cells employ regulated exocytosis of secretory granules to secrete hormones and neurotransmitters. Secretory granule exocytosis depends on spatiotemporal variables such as proximity to the plasma membrane and age, with...
3.
Michaelis A, Brunner A, Zwiebel M, Meier F, Strauss M, Bludau I, et al.
Nature
. 2023 Nov;
624(7990):192-200.
PMID: 37968396
Cellular functions are mediated by protein-protein interactions, and mapping the interactome provides fundamental insights into biological systems. Affinity purification coupled to mass spectrometry is an ideal tool for such mapping,...
4.
Thielert M, Itang E, Ammar C, Rosenberger F, Bludau I, Schweizer L, et al.
Mol Syst Biol
. 2023 Aug;
19(9):e11503.
PMID: 37602975
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we...
5.
Bhatia H, Brunner A, Ozturk F, Kapoor S, Rong Z, Mai H, et al.
Cell
. 2022 Dec;
185(26):5040-5058.e19.
PMID: 36563667
Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. However, methods for molecular analysis of large biological specimens imaged in 3D are ...
6.
Skowronek P, Thielert M, Voytik E, Tanzer M, Hansen F, Willems S, et al.
Mol Cell Proteomics
. 2022 Aug;
21(9):100279.
PMID: 35944843
Data-independent acquisition (DIA) methods have become increasingly attractive in mass spectrometry-based proteomics because they enable high data completeness and a wide dynamic range. Recently, we combined DIA with parallel accumulation-serial...
7.
Mund A, Brunner A, Mann M
Mol Cell
. 2022 Jun;
82(12):2335-2349.
PMID: 35714588
Mass spectrometry (MS)-based proteomics has become a powerful technology to quantify the entire complement of proteins in cells or tissues. Here, we review challenges and recent advances in the LC-MS-based...
8.
Mund A, Coscia F, Kriston A, Hollandi R, Kovacs F, Brunner A, et al.
Nat Biotechnol
. 2022 May;
40(8):1231-1240.
PMID: 35590073
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here, we introduce Deep Visual Proteomics (DVP), which...
9.
Cho N, Cheveralls K, Brunner A, Kim K, Michaelis A, Raghavan P, et al.
Science
. 2022 Mar;
375(6585):eabi6983.
PMID: 35271311
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically...
10.
Brunner A, Thielert M, Vasilopoulou C, Ammar C, Coscia F, Mund A, et al.
Mol Syst Biol
. 2022 Feb;
18(3):e10798.
PMID: 35226415
Single-cell technologies are revolutionizing biology but are today mainly limited to imaging and deep sequencing. However, proteins are the main drivers of cellular function and in-depth characterization of individual cells...