Andrea Perota
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Explore the profile of Andrea Perota including associated specialties, affiliations and a list of published articles.
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20
Citations
190
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Recent Articles
1.
Double transgenic neonatal porcine islets as an alternative source for beta cell replacement therapy
Mourad N, Perota A, Xhema D, Duchi R, Lagutina I, Galli C, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(46):e2409138121.
PMID: 39495930
To be clinically efficient, beta cell replacement therapies such as pig islet xenotransplantation must ensure sufficient insulin secretion from grafted islets. While protection from host immune reaction is essential for...
2.
Porta-Sanchez A, Mazzanti A, Tarifa C, Kukavica D, Trancuccio A, Mohsin M, et al.
Nat Cardiovasc Res
. 2024 Apr;
2(12):1291-1309.
PMID: 38665938
Timothy syndrome 1 (TS1) is a multi-organ form of long QT syndrome associated with life-threatening cardiac arrhythmias, the organ-level dynamics of which remain unclear. In this study, we developed and...
3.
Golia M, Frigerio R, Pucci S, Sironi F, Margotta C, Pasetto L, et al.
Exp Neurol
. 2024 Feb;
374:114716.
PMID: 38331161
SOD1 gene is associated with progressive motor neuron degeneration in the familiar forms of amyotrophic lateral sclerosis. Although studies on mutant human SOD1 transgenic rodent models have provided important insights...
4.
Casos K, Llatjos R, Blasco-Lucas A, Kuguel S, Sbraga F, Galli C, et al.
Bioengineering (Basel)
. 2023 Jul;
10(7).
PMID: 37508860
Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young...
5.
Rousse J, Royer P, Evanno G, Lheriteau E, Ciron C, Salama A, et al.
Front Immunol
. 2023 Mar;
14:1137629.
PMID: 36875084
Anti-thymocyte or anti-lymphocyte globulins (ATGs/ALGs) are immunosuppressive drugs used in induction therapies to prevent acute rejection in solid organ transplantation. Because animal-derived, ATGs/ALGs contain highly immunogenic carbohydrate xenoantigens eliciting antibodies...
6.
Cho J, Kim G, Qamar A, Fang X, Roy P, Tanga B, et al.
Zygote
. 2021 Jun;
30(1):103-110.
PMID: 34176529
This study was performed to improve production efficiency at the level of recipient pig and donor nuclei of transgenic cloned pigs used for xenotransplantation. To generate transgenic pigs, human endothelial...
7.
Vanhove B, Duvaux O, Rousse J, Royer P, Evanno G, Ciron C, et al.
bioRxiv
. 2021 May;
PMID: 34013271
Perfusion of convalescent plasma (CP) has demonstrated a potential to improve the pneumonia induced by SARS-CoV-2, but procurement and standardization of CP are barriers to its wide usage. Many monoclonal...
8.
Vanhove B, Duvaux O, Rousse J, Royer P, Evanno G, Ciron C, et al.
Eur J Immunol
. 2021 Feb;
51(6):1412-1422.
PMID: 33576494
Heterologous polyclonal antibodies might represent an alternative to the use of convalescent plasma or monoclonal antibodies (mAbs) in coronavirus disease (COVID-19) by targeting multiple antigen epitopes. However, heterologous antibodies trigger...
9.
Perota A, Galli C
Front Immunol
. 2019 Nov;
10:2396.
PMID: 31681287
The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by...
10.
Perota A, Lagutina I, Duchi R, Zanfrini E, Lazzari G, Judor J, et al.
Xenotransplantation
. 2019 May;
26(5):e12524.
PMID: 31115108
Two well-characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes...