Andrea K Byrum
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Explore the profile of Andrea K Byrum including associated specialties, affiliations and a list of published articles.
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12
Citations
435
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Recent Articles
1.
Ashour M, Byrum A, Meroni A, Xia J, Singh S, Galletto R, et al.
J Cell Biol
. 2023 Feb;
222(4).
PMID: 36795402
The primary method for probing DNA replication dynamics is DNA fiber analysis, which utilizes thymidine analog incorporation into nascent DNA, followed by immunofluorescent microscopy of DNA fibers. Besides being time-consuming...
2.
Lu D, Ellegast J, Ross K, Malone C, Lin S, Mabe N, et al.
Nat Cell Biol
. 2023 Jan;
25(2):285-297.
PMID: 36658220
Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which provides a context to precisely study the...
3.
Boone M, Taslim C, Crow J, Selich-Anderson J, Byrum A, Showpnil I, et al.
Oncogene
. 2021 Jun;
40(29):4759-4769.
PMID: 34145397
Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence of a chromosomal translocation: t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the amino-terminal domain of...
4.
Ma H, Qian W, Bambouskova M, Collins P, Porter S, Byrum A, et al.
mBio
. 2020 Mar;
11(2).
PMID: 32156810
Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible...
5.
Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, et al.
Mol Cell
. 2019 Oct;
77(1):26-38.e7.
PMID: 31653568
53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (HR). The anti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF1/shieldin effector complexes. While...
6.
Byrum A, Vindigni A, Mosammaparast N
Trends Cell Biol
. 2019 Aug;
29(9):740-751.
PMID: 31362850
The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In...
7.
Chen B, Quinet A, Byrum A, Jackson J, Berti M, Thangavel S, et al.
J Cell Biol
. 2019 May;
218(7):2113-2123.
PMID: 31123184
XRCC4-like factor (XLF) is a non-homologous end joining (NHEJ) DNA double strand break repair protein. However, XLF deficiency leads to phenotypes in mice and humans that are not necessarily consistent...
8.
Byrum A, Carvajal-Maldonado D, Mudge M, Valle-Garcia D, Majid M, Patel R, et al.
J Cell Biol
. 2019 Jan;
218(2):422-432.
PMID: 30602538
53BP1 is a chromatin-associated protein that regulates the DNA damage response. In this study, we identify the TPX2/Aurora A heterodimer, nominally considered a mitotic kinase complex, as a novel binding...
9.
Hung P, Johnson B, Chen B, Byrum A, Bredemeyer A, Yewdell W, et al.
Mol Cell
. 2018 Jul;
71(2):332-342.e8.
PMID: 30017584
The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is...
10.
Carvajal-Maldonado D, Byrum A, Jackson J, Wessel S, Lemacon D, Guitton-Sert L, et al.
Nucleic Acids Res
. 2018 Jun;
47(3):1294-1310.
PMID: 29917110
Pds5 is required for sister chromatid cohesion, and somewhat paradoxically, to remove cohesin from chromosomes. We found that Pds5 plays a critical role during DNA replication that is distinct from...