Andrea Engel
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Explore the profile of Andrea Engel including associated specialties, affiliations and a list of published articles.
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10
Citations
198
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Recent Articles
1.
Operti M, Bernhardt A, Pots J, Sincari V, Jager E, Grimm S, et al.
Pharmaceutics
. 2022 Aug;
14(8).
PMID: 36015316
Poly(lactic-co-glycolic acid) (PLGA) nanoparticle-based drug delivery systems are known to offer a plethora of potential therapeutic benefits. However, challenges related to large-scale manufacturing, such as the difficulty of reproducing complex...
2.
Operti M, Bernhardt A, Sincari V, Jager E, Grimm S, Engel A, et al.
Pharmaceutics
. 2022 Feb;
14(2).
PMID: 35214009
Despite the efficacy and potential therapeutic benefits that poly(lactic-co-glycolic acid) (PLGA) nanomedicine formulations can offer, challenges related to large-scale processing hamper their clinical and commercial development. Major hurdles for the...
3.
Schmied F, Bernhardt A, Engel A, Klein S
AAPS PharmSciTech
. 2021 Dec;
23(1):39.
PMID: 34961897
The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery systems (SNEDDSs) with a limited number of experiments. The strategic...
4.
Operti M, Bernhardt A, Grimm S, Engel A, Figdor C, Tagit O
Int J Pharm
. 2021 Jun;
605:120807.
PMID: 34144133
Nanomedicines based on poly(lactic-co-glycolic acid) (PLGA) carriers offer tremendous opportunities for biomedical research. Although several PLGA-based systems have already been approved by both the Food and Drug Administration (FDA) and...
5.
Gomes Dos Reis L, Lee W, Svolos M, Moir L, Jaber R, Engel A, et al.
Drug Dev Ind Pharm
. 2020 Feb;
46(3):427-442.
PMID: 32070151
The combination of nanoparticles (NPs) and cell-penetrating peptide (CPP) represents a new opportunity to develop plasmid DNA (pDNA) delivery systems with desirable properties for lung delivery. In this study, poly(lactide-co-glycolide)...
6.
Saraiva L, Wang L, Kammel M, Kummrow A, Atkinson E, Lee J, et al.
Cytometry B Clin Cytom
. 2019 Feb;
96(6):508-513.
PMID: 30790450
Background: Over 2,000 people a year in the United Kingdom need a bone marrow or blood stem cell transplant. It is important to accurately quantify the hematopoietic stem cells to...
7.
Albertsmeier M, Engel A, Guba M, Stintzing S, Schiergens T, Schubert-Fritschle G, et al.
Langenbecks Arch Surg
. 2017 Aug;
402(8):1223-1232.
PMID: 28803383
Purpose: The goal of this study was to analyze the use and the effectiveness of both surgery and different chemotherapies in patients with synchronous colorectal liver metastases (CLMs) ≥70 years...
8.
Stebbings R, Wang L, Sutherland J, Kammel M, Gaigalas A, John M, et al.
Cytometry A
. 2015 Feb;
87(3):244-53.
PMID: 25655255
A surface-labeled lyophilized lymphocyte (sLL) preparation has been developed using human peripheral blood mononuclear cells prelabeled with a fluorescein isothiocyanate conjugated anti-CD4 monoclonal antibody. The sLL preparation is intended to...
9.
Low K, Knobloch T, Wagner S, Wiehe A, Engel A, Langer K, et al.
Nanotechnology
. 2011 Apr;
22(24):245102.
PMID: 21508461
The second generation photosensitizer mTHPC was approved by the European Medicines Agency (EMA) for the palliative treatment of advanced head and neck cancer in October 2001. It is known that...
10.
Docke W, Hoflich C, Davis K, Rottgers K, Meisel C, Kiefer P, et al.
Clin Chem
. 2005 Oct;
51(12):2341-7.
PMID: 16214828
Background: Single-center trials have shown that monocytic HLA-DR is a good marker for monitoring the severity of temporary immunodepression after trauma, major surgery, or sepsis. A new test for measuring...