Andrea Candelli
Overview
Explore the profile of Andrea Candelli including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
406
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0
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Recent Articles
1.
Halim L, Das K, Larcombe-Young D, Ajina A, Candelli A, Benjamin R, et al.
Front Immunol
. 2022 Feb;
13:836549.
PMID: 35222427
Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells. Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a...
2.
Kosinski R, Mukhortava A, Pfeifer W, Candelli A, Rauch P, Sacca B
Nat Commun
. 2019 Mar;
10(1):1061.
PMID: 30837459
The self-assembly of a DNA origami structure, although mostly feasible, represents indeed a rather complex folding problem. Entropy-driven folding and nucleation seeds formation may provide possible solutions; however, until now,...
3.
Block J, Witt H, Candelli A, Danes J, Peterman E, Wuite G, et al.
Sci Adv
. 2018 Jun;
4(6):eaat1161.
PMID: 29928696
Structure and dynamics of living matter rely on design principles fundamentally different from concepts of traditional material science. Specialized intracellular filaments in the cytoskeleton permit living systems to divide, migrate,...
4.
Brouwer I, Moschetti T, Candelli A, Garcin E, Modesti M, Pellegrini L, et al.
EMBO J
. 2018 Mar;
37(7).
PMID: 29507080
An essential mechanism for repairing DNA double-strand breaks is homologous recombination (HR). One of its core catalysts is human RAD51 (hRAD51), which assembles as a helical nucleoprotein filament on single-stranded...
5.
Brouwer I, Sitters G, Candelli A, Heerema S, Heller I, Melo de A, et al.
Nature
. 2017 Mar;
543(7647):742.
PMID: 28329769
No abstract available.
6.
Brouwer I, Zhang H, Candelli A, Normanno D, Peterman E, Wuite G, et al.
Cell Rep
. 2017 Mar;
18(12):2845-2853.
PMID: 28329678
Human RAD52 promotes annealing of complementary single-stranded DNA (ssDNA). In-depth knowledge of RAD52-DNA interaction is required to understand how its activity is integrated in DNA repair processes. Here, we visualize...
7.
Syrjanen J, Heller I, Candelli A, Davies O, Peterman E, Wuite G, et al.
Elife
. 2017 Mar;
6.
PMID: 28287952
In a previous paper (Syrjänen et al., 2014), we reported the first structural characterisation of a synaptonemal complex (SC) protein, SYCP3, which led us to propose a model for its...
8.
Block J, Witt H, Candelli A, Peterman E, Wuite G, Janshoff A, et al.
Phys Rev Lett
. 2017 Feb;
118(4):048101.
PMID: 28186786
The mechanical properties of eukaryotic cells are to a great extent determined by the cytoskeleton, a composite network of different filamentous proteins. Among these, intermediate filaments (IFs) are exceptional in...
9.
Brouwer I, Sitters G, Candelli A, Heerema S, Heller I, de Melo A, et al.
Nature
. 2016 Jul;
535(7613):566-9.
PMID: 27437582
Non-homologous end joining (NHEJ) is the primary pathway for repairing DNA double-strand breaks (DSBs) in mammalian cells. Such breaks are formed, for example, during gene-segment rearrangements in the adaptive immune...
10.
Candelli A, Holthausen J, Depken M, Brouwer I, Franker M, Marchetti M, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(42):15090-5.
PMID: 25288749
During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles as a nucleoprotein filament around single-stranded DNA to form a catalytically proficient structure able to promote homology recognition and strand...