Andrea Bernacchia
Overview
Explore the profile of Andrea Bernacchia including associated specialties, affiliations and a list of published articles.
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9
Citations
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Recent Articles
1.
Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, et al.
J Cell Biol
. 2009 Dec;
187(7):1023-36.
PMID: 20038678
Mitochondrial fusion depends on the dynamin-like guanosine triphosphatase OPA1, whose activity is controlled by proteolytic cleavage. Dysfunction of mitochondria induces OPA1 processing and results in mitochondrial fragmentation, allowing the selective...
2.
Bernacchia A, Biondi A, Genova M, Lenaz G, Falasca A
Toxicol Mech Methods
. 2009 Dec;
14(1-2):25-30.
PMID: 20021118
The mitochondrial respiratory chain is the main source of reactive oxygen species in the cell. The main sites of superoxide radical production are within Complexes I and III; however, Complex...
3.
Martinelli P, La Mattina V, Bernacchia A, Magnoni R, Cerri F, Cox G, et al.
Hum Mol Genet
. 2009 Mar;
18(11):2001-13.
PMID: 19289403
The mitochondrial m-AAA protease has a crucial role in axonal development and maintenance. Human mitochondria possess two m-AAA protease isoenzymes: a hetero-oligomeric complex, composed of paraplegin and AFG3L2 (Afg3 like...
4.
Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, et al.
Mol Biol Cell
. 2007 Jul;
18(9):3582-90.
PMID: 17615298
The morphology of mitochondria in mammalian cells is regulated by proteolytic cleavage of OPA1, a dynamin-like GTPase of the mitochondrial inner membrane. The mitochondrial rhomboid protease PARL, and paraplegin, a...
5.
Genova M, Abd-Elsalam N, Mahdy E, Bernacchia A, Lucarini M, Pedulli G, et al.
Arch Biochem Biophys
. 2006 Feb;
447(2):167-73.
PMID: 16487923
Complex I in bovine heart submitochondrial particles catalyses the NADH-supported generation of superoxide anion; adrenaline is oxidised by superoxide to adrenochrome that, on its hand, is reduced by Complex I,...
6.
Nolden M, Ehses S, Koppen M, Bernacchia A, Rugarli E, Langer T
Cell
. 2005 Oct;
123(2):277-89.
PMID: 16239145
AAA proteases comprise a conserved family of membrane bound ATP-dependent proteases that ensures the quality control of mitochondrial inner-membrane proteins. Inactivation of AAA proteases causes pleiotropic phenotypes in various organisms,...
7.
Genova M, Pich M, Bernacchia A, Bianchi C, Biondi A, Bovina C, et al.
Ann N Y Acad Sci
. 2004 May;
1011:86-100.
PMID: 15126287
Mitochondria are known to be strong producers of reactive oxygen species (ROS) and, at the same time, particularly susceptible to the oxidative damage produced by their action on lipids, proteins,...
8.
Genova M, Pich M, Biondi A, Bernacchia A, Falasca A, Bovina C, et al.
Exp Biol Med (Maywood)
. 2003 Apr;
228(5):506-13.
PMID: 12709577
The mitochondrial respiratory chain is a powerful source of reactive oxygen species (ROS), which is considered as the pathogenic agent of many diseases and of aging. We have investigated the...
9.
Pich M, Castagnoli A, Biondi A, Bernacchia A, Tazzari P, DAurelio M, et al.
Free Radic Res
. 2002 Jun;
36(4):429-36.
PMID: 12069107
The conditions under which Coenzyme Q (CoQ) may protect platelet mitochondrial function of transfusional buffy coats from aging and from induced oxidative stress were investigated. The Pasteur effect, i.e. the...