Andre Boonstra
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Explore the profile of Andre Boonstra including associated specialties, affiliations and a list of published articles.
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160
Citations
3609
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Recent Articles
1.
Boonstra A, Sari G
Biomolecules
. 2025 Jan;
15(1).
PMID: 39858456
Hepatitis B virus (HBV) is a major global health issue, with an estimated 254 million people living with chronic HBV infection worldwide as of 2022. Chronic HBV infection is the...
2.
da Fonseca L, Izquierdo-Sanchez L, Hashizume P, Carlino Y, Baca E, Zambrano C, et al.
Lancet Reg Health Am
. 2024 Dec;
40:100952.
PMID: 39655285
Background: Cholangiocarcinoma (CCA) represents a global health challenge, with rising incidence and mortality rates. This study aimed to elucidate the clinical course and practices of CCA in Latin America. Methods:...
3.
Dongelmans E, Feld J, Boonstra A, Brakenhoff S, Wong D, Yim C, et al.
Aliment Pharmacol Ther
. 2024 Dec;
61(3):570-578.
PMID: 39624922
Background: Severe flares (ALT ≥ 10×ULN) are a well-recognised adverse outcome after nucleos(t)ide analogue (NA) cessation and may lead to liver failure. Thus, identification of patients at risk for these...
4.
Osmani Z, Brouwer W, Grashof D, Lim Y, Doukas M, Janssen H, et al.
J Hepatol
. 2024 Nov;
PMID: 39490745
Background & Aims: Patients with chronic HBV infection and concomitant metabolic dysfunction-associated steatohepatitis (MASH) have been shown to develop more severe liver disease than patients with chronic HBV alone. However,...
5.
Bosch M, Kallin N, Donakonda S, Zhang J, Wintersteller H, Hegenbarth S, et al.
Nature
. 2024 Jul;
631(8022):867-875.
PMID: 38987588
Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes. Here...
6.
Osmani Z, Beudeker B, Groothuismink Z, de Knegt R, Chung R, Aerssens J, et al.
J Infect Dis
. 2024 Jun;
230(6):e1263-e1273.
PMID: 38847286
Background: Studies on chronic hepatitis B virus (HBV) infection have shown immune dysfunction involving multiple cell types, including T cells. B cells have been evaluated more recently, but in contrast...
7.
Osmani Z, Villanueva M, Joseph-Chazan J, Beudeker B, de Knegt R, Chung R, et al.
Eur J Immunol
. 2024 May;
54(9):e2451085.
PMID: 38813721
Studies have traditionally focused on the role of T cells in chronic hepatitis B (CHB), but recent evidence supports a role for B cells. The enrichment of so-called atypical memory...
8.
Verschuren L, Mak A, van Koppen A, Ozsezen S, Difrancesco S, Caspers M, et al.
Nat Commun
. 2024 May;
15(1):4564.
PMID: 38811591
Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study applies a translational approach to develop a blood-based biomarker panel for fibrosis detection...
9.
Beudeker B, Guha R, Stoyanova K, IJzermans J, de Man R, Sprengers D, et al.
Sci Rep
. 2024 Feb;
14(1):4302.
PMID: 38383695
The incidence of hepatocellular carcinoma (HCC) in non-cirrhotic livers is rising significantly, but clear risk factors for screening remain elusive. This study sought to characterize non-cirrhotic HCC etiologies. HCC cases...
10.
Beudeker B, Osmani Z, van Oord G, Groothuismink Z, de Knegt R, Hoogenboezem R, et al.
JHEP Rep
. 2024 Feb;
6(2):100980.
PMID: 38314025
Background & Aims: HBsAg secretion may impact immune responses to chronic HBV infection. Thus, therapeutic approaches to suppress HBsAg production are being investigated. Our study aims to examine the immunomodulatory...