Andras Szarka
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Explore the profile of Andras Szarka including associated specialties, affiliations and a list of published articles.
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53
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1084
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Recent Articles
1.
Varga D, Szentirmai A, Szarka A
Molecules
. 2025 Mar;
30(5).
PMID: 40076255
Our research group aimed for the optimization of pharmacologic ascorbate (Ph-Asc)-induced cancer cell death. To reduce the required time and resources needed for development, an in silico system biological approach,...
2.
Makk-Merczel K, Varga D, Hajdinak P, Szarka A
Biofactors
. 2024 Mar;
50(5):980-996.
PMID: 38488303
Currently, a diagnosis with KRAS mutant pancreatic ductal adenocarcinoma (PDAC) means a death warrant, so finding efficient therapeutic options is a pressing issue. Here, we presented that pharmacologic ascorbate, chloroquine...
3.
Varga D, Hajdinak P, Makk-Merczel K, Szarka A
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36232313
Ferroptosis represents a typical process that has dual functions in cell fate decisions since the reduction and/or inhibition of ferroptosis is desirable for the therapies of diseases such as neurological...
4.
Szarka A, Lorincz T, Hajdinak P
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563576
An element, iron, a process, the generation of reactive oxygen species (ROS), and a molecule, ascorbate, were chosen in our study to show their dual functions and their role in...
5.
Lorincz T, Deak V, Makk-Merczel K, Varga D, Hajdinak P, Szarka A
Life (Basel)
. 2021 Aug;
11(8).
PMID: 34440600
Investigation of drug-induced liver injuries requires appropriate in vivo and in vitro toxicological model systems. In our study, an attempt was made to compare the hepatocarcinoma HepG2 and the stem...
6.
Kapuy O, Makk-Merczel K, Szarka A
Biomolecules
. 2021 Apr;
11(5).
PMID: 33925206
The Warburg effect has been considered a potential therapeutic target to fight against cancer progression. In KRAS mutant cells, PKM2 (pyruvate kinase isozyme M2) is hyper-activated, and it induces GLUT1...
7.
Holczer M, Hajdu B, Lorincz T, Szarka A, Banhegyi G, Kapuy O
Sci Rep
. 2020 Oct;
10(1):17803.
PMID: 33082544
Autophagy is an intracellular digestive process, which has a crucial role in maintaining cellular homeostasis by self-eating the unnecessary and/or damaged components of the cell at various stress events. ULK1,...
8.
Szarka A, Kapuy O, Lorincz T, Banhegyi G
Antioxid Redox Signal
. 2020 Jun;
34(11):831-844.
PMID: 32586104
Persistent oxidative stress is a common feature of cancer cells, giving a specific weapon to selectively eliminate them. Ascorbate in pharmacological concentration can contribute to the suspended formation of hydroxyl...
9.
Hajdinak P, Szabo M, Kiss E, Veress L, Wunderlich L, Szarka A
Molecules
. 2020 Apr;
25(7).
PMID: 32231024
Cyclophosphamide is one of the most potent and reliable anti-cancer and immunosuppressive drugs. In our study, 33 individuals with different autoimmune diseases were treated with cyclophosphamide according to standard protocols....
10.
Hajdinak P, Czobor A, Szarka A
PLoS One
. 2019 Dec;
14(12):e0227278.
PMID: 31887216
The iron dependent, programmed cell death, ferroptosis was described first in tumour cells. It showed distinct features from the already known cell death forms such as apoptosis, necrosis and autophagy....