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Anand Krishnan Nambisan

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Recent Articles
1.
Yarreiphang H, Vidyadhara D, Nambisan A, Raju T, Sagar B, Alladi P
Mol Neurobiol . 2023 May; 60(8):4778-4794. PMID: 37162724
Identification of genetic mutations in Parkinson's disease (PD) promulgates the genetic nature of disease susceptibility. Resilience-associated genes being unknown till date, the normal genetic makeup of an individual may be...
2.
Pougoue Ketchemen J, Babeker H, Tikum A, Nambisan A, Njotu F, Nwangele E, et al.
Br J Cancer . 2023 Apr; 129(1):153-162. PMID: 37095184
Background: HER2 is overexpressed in 25-30% of breast cancer. Multiple domains targeting of a receptor can have synergistic/additive therapeutic effects. Methods: Two domain-specific ADCs trastuzumab-PEG-DM1 (domain IV) and pertuzumab-PEG-DM1 (domain...
3.
Babeker H, Pougoue Ketchemen J, Annan Sudarsan A, Andrahennadi S, Tikum A, Nambisan A, et al.
Pharmaceutics . 2022 Dec; 14(12). PMID: 36559316
Antibodies that recognize cancer biomarkers, such as MUC16, can be used as vehicles to deliver contrast agents (imaging) or cytotoxic payloads (therapy) to the site of tumors. MUC16 is overexpressed...
4.
Tikum A, Nambisan A, Pougoue Ketchemen J, Babeker H, Khan M, Torlakovic E, et al.
Pharmaceutics . 2022 Sep; 14(9). PMID: 36145664
Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that bind to different epitopes of domain III of EGFR. We developed Zr-matuzumab as a PET probe for diagnosis/monitoring of response to treatment...
5.
Saundh S, Patnaik D, Gagne S, Bishop J, Lipsit S, Amat S, et al.
ACS Chem Neurosci . 2020 Nov; 11(24):4128-4138. PMID: 33253521
Glycogen synthase kinase 3-beta (GSK3β) is a critical regulator of several cellular pathways involved in neurodevelopment and neuroplasticity and as such is a potential focus for the discovery of new...