Anabel S Fandino
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Explore the profile of Anabel S Fandino including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
36
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Recent Articles
1.
Nagele E, Fandino A
J Chromatogr A
. 2007 Feb;
1156(1-2):196-200.
PMID: 17266968
A recent trend in the drug discovery and development process is to shift the starting point of drug metabolism and pharmacokinetic (DMPK) studies to a time as early as possible...
2.
Fandino A, Nagele E, Perkins P
J Mass Spectrom
. 2006 Jan;
41(2):248-55.
PMID: 16421870
The identification and structure elucidation of drug metabolites is one of the main objectives in in vitro ADME studies. Typical modern methodologies involve incubation of the drug with subcellular fractions...
3.
Fandino A, Rais I, Vollmer M, Elgass H, Schagger H, Karas M
J Mass Spectrom
. 2005 Aug;
40(9):1223-31.
PMID: 16127664
The application of two-dimensional electrophoresis for the identification of hydrophobic membrane proteins is principally hampered by precipitation of many of these proteins during first-dimension, isoelectric focusing. Therefore new strategies towards...
4.
Toennes S, Fandino A, Hesse F, Kauert G
J Chromatogr B Analyt Technol Biomed Life Sci
. 2003 Jul;
792(2):345-51.
PMID: 12860042
The detection of the pyrolysis product anhydroecgonine methyl ester (AEME, methylecgonidine) after cocaine smoking using gas chromatography-mass spectrometry is hampered by the artifactual production of AEME. The amount of AEME...
5.
Fandino A, Toennes S, Kauert G
J Anal Toxicol
. 2002 Dec;
26(8):567-70.
PMID: 12501914
The presence of the cocaine pyrolysis product anhydroecgonine methyl ester (AEME, methylecgonidine) in plasma indicates the smoking of cocaine. The stability of this analyte in human plasma has not been...
6.
Fandino A, Toennes S, Kauert G
Chem Res Toxicol
. 2002 Dec;
15(12):1543-8.
PMID: 12482236
During smoking of cocaine-base (crack), anhydroecgonine methyl ester (AEME, methylecgonidine) is formed in large amounts as a pyrolysis product of cocaine and is absorbed in the lungs. The metabolism of...
7.
Fandino A, Karas M, Toennes S, Kauert G
J Mass Spectrom
. 2002 Jul;
37(5):525-32.
PMID: 12112758
Cocaine is transformed into hepatotoxic metabolites through oxidative pathways. For anhydroecgonine methyl ester (AEME), the main constituent in crack smoke, the oxidative metabolism has not been studied. Therefore, incubation of...
8.
Toennes S, Schmidt K, Fandino A, Kauert G
J Anal Toxicol
. 2002 Mar;
26(1):55-7.
PMID: 11888018
Oral ingestion of allyl alcohol by a 55-year-old man resulted in death within 100 min. At autopsy, bloody, reddish fluid was found in mouth, larynx, esophagus, and trachea. The mucous...