Ana M Carvalho
Overview
Explore the profile of Ana M Carvalho including associated specialties, affiliations and a list of published articles.
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14
Citations
106
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0
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Recent Articles
1.
Carvalho A, Greene M, Smyth P, Mutch A, McLaughlin K, Cairns L, et al.
Biomacromolecules
. 2024 Sep;
25(10):6503-6514.
PMID: 39235263
Paediatric acute myeloid leukemia (AML) is a heterogeneous hematological malignancy still heavily reliant on traditional chemotherapeutic approaches. Combination treatments have shown to be a superior approach, but their success is...
2.
Pereira Santos S, Guedes S, Pesqueira R, Stuart J, Carvalho A, Correia P, et al.
Rev Port Cardiol
. 2024 Jul;
43(11):601-610.
PMID: 39004141
Introduction And Objectives: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal, thus it is important to identify individuals at risk. Patients with hypertension have an...
3.
Carvalho A, Reis R, Pashkuleva I
Adv Healthc Mater
. 2022 Nov;
12(5):e2202118.
PMID: 36373221
The tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer-associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that...
4.
Carvalho A, Valcarcel J, Soares da Costa D, Gomes M, Vazquez J, Reis R, et al.
ACS Appl Mater Interfaces
. 2022 Sep;
14(37):41779-41789.
PMID: 36053163
We report on the synthesis of hyaluronan (HA) brush-like copolymers and their application as antagonists of tumorigenic CD44-HA interactions. HA (4.8 kDa, ca. 24 saccharides) was grafted on 2-hydrohyethyl methacrylate...
5.
Carvalho A, Soares da Costa D, Reis R, Pashkuleva I
Acta Biomater
. 2022 May;
146:187-196.
PMID: 35577044
Hyaluronan (HA) synthesis and degradation are altered during carcinogenesis leading to an increased HA content in the tumor microenvironment, which correlates with poor prognosis and treatment outcomes. The main HA...
6.
Carvalho A, Soares da Costa D, Reis R, Pashkuleva I
Adv Healthc Mater
. 2021 Oct;
11(4):e2101309.
PMID: 34694735
Molecular gradients are common in biosystems and play an essential role in physiological and pathological processes. During carcinogenesis, for example, hyaluronan (HA) homeostasis is dysregulated by cancer cells and the...
7.
Dominguez-Arca V, Costa R, Carvalho A, Taboada P, Reis R, Prieto G, et al.
Mater Sci Eng C Mater Biol Appl
. 2021 Feb;
121:111813.
PMID: 33579457
Extracellular vesicles (EVs) are particles originating from the exfoliation of the cellular membrane. They are involved in cell-to-cell and cell-to-matrix signaling, exchange of bioactive molecules, tumorigenesis and metastasis, among others....
8.
Ribeiro S, Carvalho A, Fernandes E, Gomes M, Reis R, Bayon Y, et al.
Acta Biomater
. 2020 Nov;
121:303-315.
PMID: 33227488
Although it has been repeatedly indicated the importance to develop implantable devices and cell culture substrates with tissue-specific rigidity, current commercially available products, in particular cell culture substrates, have rigidity...
9.
Carvalho A, Soares da Costa D, Paulo P, Reis R, Pashkuleva I
Acta Biomater
. 2020 Oct;
119:114-124.
PMID: 33091625
CD44 and the receptor for hyaluronic acid-mediated motility (RHAMM) are the main hyaluronan (HA) receptors. They are commonly overexpressed in different cancers activating signaling pathways related to tumor progression, metastasis...
10.
Carvalho A, Fernandes E, Goncalves H, Giner-Casares J, Bernstorff S, Nieder J, et al.
Int J Pharm
. 2020 Mar;
580:119222.
PMID: 32194209
Interactions of paclitaxel (PTX) with models mimicking biological interfaces (lipid membranes and serum albumin, HSA) were investigated to test the hypothesis that the set of in vitro assays proposed can...