Ana I Moreno-Manuel
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Explore the profile of Ana I Moreno-Manuel including associated specialties, affiliations and a list of published articles.
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6
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12
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Recent Articles
1.
Mondejar-Parreno G, Moreno-Manuel A, Ruiz-Robles J, Jalife J
Cell Discov
. 2025 Jan;
11(1):3.
PMID: 39788950
A well-balanced ion channel trafficking machinery is paramount for the normal electromechanical function of the heart. Ion channel variants and many drugs can alter the cardiac action potential and lead...
2.
Cruz F, Moreno-Manuel A, Perez P, Ruiz-Robles J, Socuellamos P, Gutierrez L, et al.
medRxiv
. 2024 Dec;
PMID: 39711719
Background: Flecainide and other class-Ic antiarrhythmic drugs (AADs) are widely used in Andersen-Tawil syndrome type 1 (ATS1) patients. However, class-Ic drugs might be proarrhythmic in some cases. We investigated the...
3.
Macias A, Gonzalez-Guerra A, Moreno-Manuel A, Cruz F, Gutierrez L, Garcia-Quintans N, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(10):900-917.
PMID: 39195979
Andersen-Tawil syndrome type 1 (ATS1) is associated with life-threatening arrhythmias of unknown mechanism. In this study, we generated and characterized a mouse model of ATS1 carrying the trafficking-deficient mutant Kir2.1...
4.
Extracellular Kir2.1 Mutant Upsets Kir2.1-PIP Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome
Cruz F, Macias A, Moreno-Manuel A, Gutierrez L, Vera-Pedrosa M, Martinez-Carrascoso I, et al.
Circ Res
. 2024 Mar;
134(8):e52-e71.
PMID: 38497220
Background: Andersen-Tawil syndrome type 1 is a rare heritable disease caused by mutations in the gene coding the strong inwardly rectifying K channel Kir2.1. The extracellular Cys (cysteine)-to-Cys disulfide bond...
5.
Moreno-Manuel A, Macias A, Cruz F, Gutierrez L, Martinez F, Gonzalez-Guerra A, et al.
Cardiovasc Res
. 2024 Jan;
120(5):490-505.
PMID: 38261726
Aims: Short QT syndrome type 3 (SQTS3) is a rare arrhythmogenic disease caused by gain-of-function mutations in KCNJ2, the gene coding the inward rectifier potassium channel Kir2.1. We used a...
6.
Gutierrez L, Moreno-Manuel A, Jalife J
Heart Rhythm
. 2024 Jan;
21(5):630-646.
PMID: 38244712
Sudden cardiac death in children and young adults is a relatively rare but tragic event whose pathophysiology is unknown at the molecular level. Evidence indicates that the main cardiac sodium...
7.
Cruz F, Macias A, Moreno-Manuel A, Gutierrez L, Vera-Pedrosa M, Martinez-Carrascoso I, et al.
bioRxiv
. 2023 Jun;
PMID: 37333254
Background: Andersen-Tawil Syndrome Type 1 (ATS1) is a rare heritable disease caused by mutations in the strong inwardly rectifying K channel Kir2.1. The extracellular Cys122-to-Cys154 disulfide bond in the Kir2.1...