Ana Frank-Garcia
Overview
Explore the profile of Ana Frank-Garcia including associated specialties, affiliations and a list of published articles.
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26
Citations
2954
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Recent Articles
1.
Garcia-Alberca J, de Rojas I, Sanchez-Mejias E, Garrido-Martin D, Gonzalez-Palma L, Jimenez S, et al.
J Alzheimers Dis
. 2024 Mar;
98(2):601-618.
PMID: 38427484
Background: Microglial dysfunction plays a causative role in Alzheimer's disease (AD) pathogenesis. Here we focus on a germline insertion/deletion variant mapping SIRPβ1, a surface receptor that triggers amyloid-β(Aβ) phagocytosis via...
2.
Fernandez-Fournier M, Lopez-Molina M, Torres Iglesias G, Botella L, Chamorro B, Laso-Garcia F, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762495
We aimed to analyze whether EVs carry antibodies against EBV antigens and the possibility that they could serve as diagnostic and disease activity blood biomarkers in RRMS. This was a...
3.
de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen I, et al.
Nat Commun
. 2023 Feb;
14(1):716.
PMID: 36759603
No abstract available.
4.
Bellenguez C, Kucukali F, Jansen I, Kleineidam L, Moreno-Grau S, Amin N, et al.
Nat Genet
. 2022 Apr;
54(4):412-436.
PMID: 35379992
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage...
5.
de Rojas I, Hernandez I, Montrreal L, Quintela I, Calero M, Royo J, et al.
J Pers Med
. 2021 Dec;
11(12).
PMID: 34945790
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using...
6.
de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen I, et al.
Nat Commun
. 2021 Jun;
12(1):3417.
PMID: 34099642
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials....
7.
Kristen H, Sastre I, Aljama S, Fuentes M, Recuero M, Frank-Garcia A, et al.
Neurochem Int
. 2021 Mar;
146:105032.
PMID: 33781848
Mounting evidence suggests a major role of infectious agents in the pathogenesis of sporadic Alzheimer's disease (AD). Among them, herpes simplex virus type 1 (HSV-1) infection has emerged as a...
8.
de Vidania S, Palomares-Perez I, Frank-Garcia A, Saito T, Saido T, Draffin J, et al.
Front Neurosci
. 2020 Dec;
14:562581.
PMID: 33343276
In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical...
9.
Belbin O, Morgan K, Medway C, Warden D, Cortina-Borja M, Van Duijn C, et al.
J Alzheimers Dis
. 2019 Mar;
68(4):1535-1547.
PMID: 30909233
Pre-synaptic secretion of brain-derived neurotrophic factor (BDNF) from noradrenergic neurons may protect the Alzheimer's disease (AD) brain from amyloid pathology. While the BDNF polymorphism (rs6265) is associated with faster cognitive...
10.
Sims R, van der Lee S, Naj A, Bellenguez C, Badarinarayan N, Jakobsdottir J, et al.
Nat Genet
. 2017 Jul;
49(9):1373-1384.
PMID: 28714976
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage...