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Ana C Sias

Explore the profile of Ana C Sias including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 375
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Recent Articles
1.
Giovanniello J, Paredes N, Wiener A, Ramirez-Armenta K, Oragwam C, Uwadia H, et al.
Nature . 2025 Feb; PMID: 39972126
Chronic stress can change how we learn and, thus, how we make decisions. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in...
2.
Malvaez M, Liang A, Hall B, Giovanniello J, Paredes N, Gonzalez J, et al.
bioRxiv . 2025 Feb; PMID: 39896502
Adaptive decision making requires agency, knowledge that actions produce particular outcomes. For well-practiced routines, agency is relinquished in favor of habit. Here, we asked how dorsomedial striatum D1 and D2/A2A...
3.
Sias A, Jafar Y, Goodpaster C, Ramirez-Armenta K, Wrenn T, Griffin N, et al.
Nat Neurosci . 2024 Feb; 27(4):728-736. PMID: 38396258
To make adaptive decisions, we build an internal model of the associative relationships in an environment and use it to make predictions and inferences about specific available outcomes. Detailed, identity-specific...
4.
Giovanniello J, Paredes N, Wiener A, Ramirez-Armenta K, Oragwam C, Uwadia H, et al.
bioRxiv . 2023 Oct; PMID: 37873076
Chronic stress can change how we learn and, thus, how we make decisions. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in...
5.
Sias A, Morse A, Wang S, Greenfield V, Goodpaster C, Wrenn T, et al.
Elife . 2021 Jun; 10. PMID: 34142660
Adaptive reward-related decision making often requires accurate and detailed representation of potential available rewards. Environmental reward-predictive stimuli can facilitate these representations, allowing one to infer which specific rewards might be...
6.
Brown J, Deng J, Neuhaus J, Sible I, Sias A, Lee S, et al.
Neuron . 2019 Oct; 104(5):856-868.e5. PMID: 31623919
Neurodegenerative diseases appear to progress by spreading via brain connections. Here we evaluated this transneuronal degeneration hypothesis by attempting to predict future atrophy in a longitudinal cohort of patients with...
7.
Lee S, Sias A, Kosik E, Flagan T, Deng J, Chu S, et al.
Neuroimage Clin . 2019 Mar; 22:101751. PMID: 30921613
Mutations in progranulin (GRN) cause heterogeneous clinical syndromes, including behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), corticobasal syndrome (CBS) and Alzheimer-type dementia (AD-type dementia). Human studies have shown...
8.
Meeter L, Gendron T, Sias A, Jiskoot L, Russo S, Donker Kaat L, et al.
Ann Clin Transl Neurol . 2018 May; 5(5):583-597. PMID: 29761121
Objective: To evaluate poly(GP), a dipeptide repeat protein, and neurofilament light chain (NfL) as biomarkers in presymptomatic repeat expansion carriers and patients with associated frontotemporal dementia. Additionally, to investigate the...
9.
Perry D, Brown J, Possin K, Datta S, Trujillo A, Radke A, et al.
Brain . 2017 Oct; 140(12):3329-3345. PMID: 29053860
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical for the success of disease-modifying therapies....
10.
Lee S, Sias A, Mandelli M, Brown J, Brown A, Khazenzon A, et al.
Neuroimage Clin . 2017 Mar; 14:286-297. PMID: 28337409
Hexanucleotide repeat expansions in are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous work has shown that patients with behavioral variant...